Results 101 to 110 of about 149,105 (224)

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Colorectal cancer [PDF]

, 2007
Adenomatous polyps are the known precursors of the majority of colorectal cancers, with the risk of malignancy increasing with increasing polyp size.
Vassallo, Pierre
core  

Trends in colorectal cancer mortality in Europe : retrospective analysis of the WHO mortality database [PDF]

, 2015
Objective: To examine changes in colorectal cancermortality in 34 European countries between 1970 and 2011. Design: Retrospective trend analysis. Data source: World Health Organization mortality database. Population: Deaths from colorectal cancer between
Autier, Philippe, Bleiberg, Harry, Boniol, Magali, Boniol, Mathieu, Bota, Maria, Jenkins, Mark A, Malvezzi, Matteo, Negri, Eva, Ouakrim, Driss Ait, Pizot, Cécile   +9 more
core   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Cost-benefit analysis of a colorectal cancer screening program using fecal DNA testing as initial screening: a hospital-based study in Wuhan, China

Zhongguo gonggong weisheng
ObjectiveTo analyze the cost-effectiveness of a colorectal cancer screening program using fecal DNA testing as initial screening in Wuhan, Hubei province, and to provide evidence for colorectal cancer screening decision making.
Yueming LI, Yuying WANG, Duan ZHUO, Jiaqian PENG, Ruijingfang JIANG, Hao WU, Shunyao WANG, Song LIU, Lijian ZHAO, Jian WANG, Bing MAO, Shida ZHU, Hongbing TAO   +12 more
doaj   +1 more source

Colorectal cancer in Malaysia: Its burden and implications for a multiethnic country

Asian Journal of Surgery, 2017
Background: This study aims to provide an analytical overview of the changing burden of colorectal cancer and highlight the implementable control measures that can help reduce the future burden of colorectal cancer in Malaysia.
Sajesh K. Veettil, Kean Ghee Lim, Nathorn Chaiyakunapruk, Siew Mooi Ching, Muhammad Radzi Abu Hassan   +4 more
doaj   +1 more source

Colorectal Cancer: Epidemiological Trends, Screening, and Inheritability [PDF]

, 2018
Colorectal cancer is one of the most common cancer worldwide. The incidence and mortality trend in different areas of the world varies. Colorectal cancer incidence and mortality are increasing in some countries.
Maulahela, H. (Hasan), Paramita, I. A. (Isabela), Winston, K. (Kevin)   +2 more
core  

Clinical management of endoscopically resected pT1 colorectal cancer [PDF]

, 2018
Background Implementation of colorectal cancer (CRC) screening programs increases endoscopic resection of polyps with early invasive CRC (pT1). Risk of lymph node metastasis often leads to additional surgery, but despite guidelines, correct management ...
Angeletti, Stefano, Antonelli, Giulio, Berardi, Giammauro, Brescia, Antonio, Corleto, Vito Domenico, D'Ambra, Giancarlo, Di Giulio, Emilio, Hassan, Cesare, Mercantini, Paolo, Pilozzi, Emanuela, Rampioni Vinciguerra, Gian Luca, Ruggeri, Maurizio   +11 more
core   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source