Results 121 to 130 of about 4,110,582 (295)

Study protocol for a mixed methods approach to optimize colorectal cancer screening in Malaysia: Integrating stakeholders insights and knowledge-to-action framework.

PLoS ONE
IntroductionColorectal cancer is a growing global health concern and the number of reported cases has increased over the years. Early detection through screening is critical to improve outcomes for patients with colorectal cancer.
Diane Woei-Quan Chong, Vivek Jason Jayaraj, Fathullah Iqbal Ab Rahim, Sharifah Saffinas Syed Soffian, Muhammad Fikri Azmi, Mohd Yusaini Mohd Yusri, Ahmad Shanwani Mohamed Sidek, Norfarizan Azmi, Rosaida Md Said, Muhammad Firdaus Md Salleh, Norasiah Abu Bakar, Hamiza Shahar, Rima Marhayu Abdul Rashid, Shazimah Abdul Samad, Zanita Ahmad, Mohd Safiee Ismail, Adilah A Bakar, Nor Mashitah Hj Jobli, Sondi Sararaks   +18 more
doaj   +1 more source

First reports of computed tomographic colonography for the screening of colorectal polyps in acromegalic patients [PDF]

, 2008
*Aim:* To analyze the CTC performance for the screening of colorectal polyps in acromegalic patients. *Materials and Methods:* A prospective study of 21 acromegalic patients, 12 male and 9 female, average age 49, who underwent CTC ...
Odery Ramos Jr, César Luiz Boguszewski, Júlio César Pisani, Benito Parolim, Sandra Teixeira, Ricardo De Bem, Anke Boeving, João Carlos Prolla   +7 more
core  

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Colorectal cancer screening: assessment of physicians’ knowledge, attitude and practice in tertiary healthcare centers of plateau state, Nigeria

Ibom Medical Journal
Background: Colorectal cancer is the second most common cause of cancer death and third most commonly diagnosed cancer worldwide. The incidence is projected to rise steeply in the nearest future with a high burden in low- and middle-income countries ...
Akpa PO, Kwaghe BV, Emmanuel I, David NP, Adedeji BK, Ibeanu CN, Onota PO, Othman IA, Ben JE, Emmanuel JA, Bahaushe NZ, Agabus NM, Dauda AM, Silas OA, Mandong BM, Nantok D   +15 more
doaj   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Using cell‐free RNA to identify B‐ and T‐cell clonality for diagnosis and monitoring of B‐ and T‐cell neoplasms

FEBS Open Bio, EarlyView.
Using peripheral blood for determining B‐cell or T‐cell clonality is more reliable when we use cell‐free RNA (cfRNA) because cells release blood significantly more RNA than DNA. Next‐generation sequencing (NGS) of cfRNA allows us to evaluate fragment cfRNA and evaluate clonality reliably without the need for prior determination of the specific dominant
Adam Albitar, Sally Agersborg, Ahmed Charifa, Pooja Phull, Noa Biran, David Vesole, Harsh Parmar, Andrew Pecora, Andrew Ip, Andre Goy, David Siegel, Maher Albitar   +11 more
wiley   +1 more source

Knowledge, attitude, and practice of primary care physicians about colon cancer screening tests and referrals in Saudi Arabia: A systematic review and meta-analysis

Journal of Family Medicine and Primary Care
Colorectal cancer is a major public health concern worldwide, and early detection through screening significantly reduces mortality. Primary care physicians (PCPs) play a crucial role in recommending and facilitating colorectal cancer screening.
Abdullah Muhammad Aziz, Rayan H. Almutairi, Mohammed Khalid Alghomari, Abdulelah Talal Almaghrabi, Turki Majed Al-Qahtani, Ahmed Amer Alsaiari, Mohammed Abdullah Alfawaz   +6 more
doaj   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Patient Portal Use and Cancer Screening in the United States: Individual Associations and Population Impact

Journal of Primary Care & Community Health
Objectives Cancer screening uptake in the United States remains below national targets despite established screening recommendations. Patient portals may support preventive care delivery, but their association with cancer screening uptake and population ...
Rida Ejaz MBBS, Odysseas P. Chatzipanagiotou MD, Qaidar Alizai MD, MRCS, Azza Sarfraz MD, Charalampos M. Charalampous MD, Abdulaziz Elemosho MD, Rabia Bega MBBS, MPH, Timothy M. Pawlik MD, PhD, MPH, MTS, MBA   +7 more
doaj   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source