Results 51 to 60 of about 4,110,582 (295)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Increasing deaths from colorectal cancer in Poland – Insights for optimising colorectal cancer screening in society and space

Annals of Agricultural and Environmental Medicine, 2019
Introduction and objective With respect to the increasing numbers of deaths due to colorectal cancer in Poland, the aim of the study was to investigate socio-demographic characteristics which influence colorectal cancer screening acceptance and to assess
Krzysztof Czaderny
doaj   +1 more source

Motivational Interviewing to Improve the Uptake of Colorectal Cancer Screening: A Systematic Review and Meta-Analysis

Frontiers in Medicine, 2022
IntroductionColorectal cancer screening when done early can significantly reduce mortality. However, screening compliance is still lower than expected even in countries with established screening programs.
Novia Niannian Long, Michele Petrova Xin Ling Lau, Ainsley Ryan Yan Bin Lee, Natalie Elizabeth Yam, Nicholas Ye Kai Koh, Cyrus Su Hui Ho   +5 more
doaj   +1 more source

Inequalities in colorectal cancer screening participation in the first round of the national screening programme in England [PDF]

, 2009
BACKGROUND: Introduction of organised, population-based, colorectal cancer screening in the United Kingdom using the faecal occult blood test (FOBT) has the potential to reduce overall colorectal cancer mortality.
Wright, D, S Bloom, J Wardle (16144280), D Wright, C von Wagner (16144274), C von Wagner, B Rachet, Rachet, B, von Wagner, C, J Wardle, S Bloom (13470937), A Good (13398663), A Good, A Obichere (16144292), Bloom, S, Obichere, A, D Wright (7642556), Good, A, Wardle, J, A Obichere, B Rachet (16144289)   +20 more
core   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

The impact of a bodyweight and physical activity intervention (BeWEL) initiated through a national colorectal cancer screening programme: randomised controlled trial [PDF]

, 2014
Objective: To evaluate the impact of a diet and physical activity intervention (BeWEL) on weight change in people with a body mass index >25 weight (kg)/height (m)2 at increased risk of colorectal cancer and other obesity related comorbidities. Design:
Belch, Jill J F, Steele, Robert J C, Rauchhaus, Petra, Belch, Jill, Daly, Fergus, Kirk, Alison, Stead, Martine, Wardle, Jane, Rauchaus, Petra, Anderson, Annie S, Treweek, Shaun, Macleod, Maureen, Rodger, Jackie, Caswell, Stephen, Ludbrook, Anne, Belch, Jill; id_orcid, Anderson, Annie S., Craigie, Angela M, Steele, Robert JC, Steele, Robert, Thompson, Joyce, Craigie, Angela, Anderson, Annie S.; id_orcid, Norwood, Patricia, Craigie, Angela M.; id_orcid, Craigie, Angela M.   +25 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Colorectal Cancer Screening: A Guide to the Guidelines

Canadian Journal of Gastroenterology, 1999
The two most recent guidelines for colorectal cancer screening are those of the Agency for Healthcare Policy and Research, and the American Cancer Society.
Douglas K Rex
doaj   +1 more source