Results 241 to 250 of about 360,581 (300)

Tumor‐Derived Exosomal TAGLN2 Promotes Metastasis by Inducing Vascular Permeability and Angiogenesis via the NRP1/SEMA4D/YAP Axis

Advanced Science, EarlyView.
Gastric cancer‐derived exosomal TAGLN2 is identified as a key mediator of vascular reprogramming, with significantly elevated levels detected in patient serum. Independent of canonical SEMA4D signaling, it nucleates a cytoplasmic TAGLN2/NRP1/SEMA4D ternary complex that dually activates YAP, promoting angiogenesis, vascular dysfunction, and metastasis ...
Shuqi Yu, Jiajia Zhuo, Xiaoquan Hong, Shihao Rao, Yafang Ye, Dandan Kang, Huifang Peng, Huiqin Zhuo   +7 more
wiley   +1 more source

Epithelial TRIM27 Inhibits Intestinal Inflammation in Ulcerative Colitis by the USP7/TRIM27‐IKK Double Negative‐Feedback

Advanced Science, EarlyView.
ABSTRACT The E3 ubiquitin ligase tripartite motif 27 (TRIM27) is a negative regulator of NF‐κB activation and the innate immune response, and TRIM27 deficiency significantly impairs dextran sulfate sodium (DSS)‐induced colitis. The function of TRIM27 in intestinal epithelial cells (IECs), the mechanism by which TRIM27 inhibits the NF‐κB pathway and its
Weimin Xu, Zhebin Hua, Zhujiang Dai, Shasha Zhang, Yihan Jiang, Wensong Ge, YingWei Chen, Zhongchuan Wang, Bing Zhang, Chen‐Ying Liu, Peng Du   +10 more
wiley   +1 more source

Mortality trends from colorectal pathologies in the United States (1999-2020): a retrospective cohort study using CDC WONDER. [PDF]

Tech Coloproctol
Rogers JL, Ali D, Khan A.
europepmc   +1 more source

POU2F1 Promotes Chemoresistance in Colorectal Cancer Cells via Attenuates the MDR2 Degradation Mediated by PPP1R11 Lactylation

Advanced Science, EarlyView.
Schematic diagram of our study showing that highly expressed POU2F1 in colorectal cancer (CRC) can directly accelerate the cytosolic lactate export to decrease PPP1R11 lactylation at K59, thereby attenuating the E3 ligase enzyme activity and protein stability of PPP1R11, which inhibits the ubiquitination of MDR2 at K413 and K538 but increases the ...
Longzheng Xia, Jinguan Lin, Xianjie Jiang, Linda Oyang, Shiming Tan, Zongyao Ren, Qiu Peng, Qianjin Liao, Yujuan Zhou   +8 more
wiley   +1 more source

External Auditory Canal Metastasis of Colorectal Adenocarcinoma: A Comprehensive Case Report. [PDF]

Clin Case Rep
Sissa L, Cardelli S, Malvi D, Poggioli G, Rottoli M, Calini G.   +5 more
europepmc   +1 more source

Completion Colonoscopy: Should We Select the Endoscopist Based on Which Noninvasive Colorectal Cancer Screening Test was Positive? [PDF]

Clin Transl Gastroenterol
Jacobson BC.
europepmc   +1 more source

Synchronous Gastric Metastasis From Sigmoid Colon Cancer: A Case Report. [PDF]

Clin Case Rep
Oh SJ, Oh SG, Choi SK.
europepmc   +1 more source

Metabolic factors associated with colorectal neoplasms: a single center retrospective cross-sectional analysis of colonoscopy patients. [PDF]

BMC Gastroenterol
Arai J, Fujiwara H, Aoki T, Niikura R, Ihara S, Suzuki N, Tsuji Y, Hayakawa Y, Kasuga M, Fujishiro M.   +9 more
europepmc   +1 more source

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Atypical Colorectal Neoplasms

Surgical Clinics of North America, 2017
Primary colorectal lymphoma, carcinoids (neuroendocrine tumors), and gastrointestinal stromal tumors comprise a small subset of all colorectal cancers. Their features are unique, and their treatment varies from that of colorectal adenocarcinoma. Appropriate identification is key in the management of these tumors.
Michael G, Porter, Scott M, Stoeger
openaire   +2 more sources

Colorectal neoplasm and acromegaly

Pituitary, 2006
The risk for colorectal carcinoma in acromegaly remains controversial. In our earlier study, we have demonstrated that the risk of colorectal carcinoma in Asian Indians with acromegaly is not increased and after this report, routine colonoscopy in our patients with acromegaly was abandoned.
Anil, Bhansali, Pinaki, Dutta, Mohammad Hayat, Bhat, S K, Sinha, R, Kochar, K, Vaiphi   +5 more
openaire   +2 more sources