Results 71 to 80 of about 332,251 (304)

Expression of Ciclooxigenase-2 in colorectal carcinoma, a narrative review

Iatreia, 2019
The development of colorectal carcinoma is a sequential process associated to chromosomic instability and to mutations of oncogenes as KRAS, of tumor suppressor gene as p53, or loss of APC, leading to uncontrolled cell proliferation and transformation ...
Benedetti Padrón, Inés, Becerra Mejía, Daniel   +1 more
doaj   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Palliative primary tumor resection may not offer survival benefits for patients with unresectable metastatic colorectal neuroendocrine neoplasms, one multicenter retrospective cohort study [PDF]

, 2022
Zhijie Wang, Hongchang Ren, Li Li, Qian Liu   +3 more
openalex   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Current Status of Chemotherapy in Colorectal Cancer: Updated Treatment Strategies

The Korean Journal of Gastroenterology
Colorectal cancer remains a significant health burden in South Korea, being the third most diagnosed cancer in the country. Despite advances in treatment, patients with metastatic colorectal cancer still face limited survival rates, with resection often ...
Jae Hyun Kim, Seun Ja Park
doaj   +1 more source

Characterization of elderly with diagnosis of colorectal neoplasm

Medisan, 2021
Introduction: The colorectal cancer is the most frequent neoplasia of the digestive tract in elderly, as well as the fourth more diagnosed in men and the third in women.
Yon Luis Trujillo Pérez, Yosvany Rojas Peláez, Marelen Pérez González, Edilberto Machado del Risco, José Andrés Calzadilla Cuza   +4 more
doaj  

Central obesity and atherogenic dyslipidemia in metabolic syndrome are associated with increased risk for colorectal adenoma in a Chinese population

BMC Gastroenterology, 2010
Background Metabolic syndrome (MetS) is composed of cardiovascular risk factors including insulin resistance, obesity, dyslipidemia, and hypertension. Most of the components of MetS have been linked to the development of neoplasm.
Lin Tsann, Lin Wen-Yuan, Li Tsai-Chung, Jan Chia-Ing, Li Chia-Ing, Hsu Hua-Shui, Liu Chiu-Shong, Chen Ya-Chien, Lee Cheng-Chun, Lin Cheng-Chieh   +9 more
doaj   +1 more source

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

Mutations in the P53 Tumor Suppressor Gene in Colorectal Cancer in Taiwan

Kaohsiung Journal of Medical Sciences, 2003
Mutations in the tumor suppressor gene p53 have been reported as occurring prevalently in a wide range of human tumors. Detection of a mutated p53 is thought to provide useful information for the clinical management of colorectal neoplasm. In this study,
Fu-Hsin Chang, Dong-Sheng Tzeng, For-Wey Lung   +2 more
doaj   +1 more source