Results 91 to 100 of about 638,404 (291)

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Descoberta simultânea de carcinomatose disseminada e carcinoma de cólon, após colecistectomia laparoscópica

Revista do Colégio Brasileiro de Cirurgiões
A particularly rapid and fatal outcome has been noted in cases of malignant soft-tissue metastases occurring after cancer surgery. Abdominal wall metastases occurring in scars after laparotomy for cancer resection show a similar poor outcome.
João Luiz M. C. Azevedo, Délcio Mattos, Otávio Azevedo   +2 more
doaj   +1 more source

Characterization of elderly with diagnosis of colorectal neoplasm

Medisan, 2021
Introduction: The colorectal cancer is the most frequent neoplasia of the digestive tract in elderly, as well as the fourth more diagnosed in men and the third in women.
Yon Luis Trujillo Pérez, Yosvany Rojas Peláez, Marelen Pérez González, Edilberto Machado del Risco, José Andrés Calzadilla Cuza   +4 more
doaj  

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Hepatectomia direita no tratamento da metástase hepática do carcinoma colorretal

Revista do Colégio Brasileiro de Cirurgiões
OBJETIVO: As metástases hepáticas do carcinoma colorretal, constituem-se, atualmente, em doença potencialmente curável, através dos diversos tipos de ressecções hepáticas, entre as quais se sobressai a hepatectomia direita.
Fernando César Façanha Fonseca, Jacques Belghiti, Guilherme Pinto Bravo Neto, Gerson Suguiyama Nakajima   +3 more
doaj   +1 more source

Cutaneous metastasis as the first sign of colorectal cancer: a case report [PDF]

Kosin Medical Journal
Cutaneous metastases from colorectal cancer are rare, occurring in only 0.7%–5% of cases. They typically develop in the late stages of the disease and indicate widespread dissemination and poor prognosis.
Gyuyeong Kim, Jaeil Chung, Donghui Kim, Kyoohyun Park, Haegwang Shin, Hongsik Lee, Wonjai Hur, Yoosuk Suh   +7 more
doaj   +1 more source

Association between TAS2R38 gene polymorphisms and colorectal cancer risk [PDF]

, 2011
Molecular sensing in the lingual mucosa and in the gastro-intestinal tract play a role in the detection of ingested harmful drugs and toxins. Therefore, genetic polymorphisms affecting the capability of initiating these responses may be critical for the ...
Stemmler, Susanne, Novotny, Jan, Steinke, Verena, Vodicka, Pavel, Morak, Monika, Hemminki, Kari, Pardini, Barbara, Engel, Christoph, Canzian, Federico, Schackert, Hans K., Naccarati, Alessio, Vodickova, Ludmila, Görgens, Heike, Propping, Peter, Barale, Roberto, Büttner, Reinhard, Försti, Asta, Carrai, Maura, Betz, Beate, Holinski-Feder, Elke, Stein, Angelika, Kloor, Matthias, Rahner, Nils, Campa, Daniele   +23 more
core   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Central obesity and atherogenic dyslipidemia in metabolic syndrome are associated with increased risk for colorectal adenoma in a Chinese population

BMC Gastroenterology, 2010
Background Metabolic syndrome (MetS) is composed of cardiovascular risk factors including insulin resistance, obesity, dyslipidemia, and hypertension. Most of the components of MetS have been linked to the development of neoplasm.
Lin Tsann, Lin Wen-Yuan, Li Tsai-Chung, Jan Chia-Ing, Li Chia-Ing, Hsu Hua-Shui, Liu Chiu-Shong, Chen Ya-Chien, Lee Cheng-Chun, Lin Cheng-Chieh   +9 more
doaj   +1 more source

Colorectal neoplasia in Asia: a multicenter colonoscopy survey in symptomatic patients

, 2006
Background: The incidence of colorectal cancer is rising rapidly in some Asian countries. Objective: To determine the prevalence and the distribution of colorectal neoplasm in Asian populations.
김원호
core   +1 more source