Results 101 to 110 of about 638,404 (291)

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Mutations in the P53 Tumor Suppressor Gene in Colorectal Cancer in Taiwan

Kaohsiung Journal of Medical Sciences, 2003
Mutations in the tumor suppressor gene p53 have been reported as occurring prevalently in a wide range of human tumors. Detection of a mutated p53 is thought to provide useful information for the clinical management of colorectal neoplasm. In this study,
Fu-Hsin Chang, Dong-Sheng Tzeng, For-Wey Lung   +2 more
doaj   +1 more source

Colorectal cancer: a comparative study of models of health care delivery in two adjacent trusts in South Wales [PDF]

, 2012
Introduction Survival in colorectal cancer patients is dependant on the stage of the cancer at diagnosis. Referral via an appropriate pathway to a specialist service is vital to the early detection of colorectal cancer but there is neither a standard ...
Shah, Parin Rajendra
core  

Evaluation of the accuracy of serum MMP-9 as a test for colorectal cancer in a primary care population [PDF]

, 2006
Background Bowel cancer is common and is a major cause of death. Meta-analysis of randomised controlled trials estimates that screening for colorectal cancer using faecal occult blood (FOB) test reduces mortality from colorectal cancer by 16%.
Redman, VD, Michael JO Wakelam, Colbourne, L, Janet A Dunn, Val D Redman, Lynne Colbourne, Dunn, Janet, Martin, A, Martin Ashley, Wilson, S, Wakelam, Michael, Ismail, T, Hobbs Richard FD, Wakelam, Michael J.O., Sue Wilson, Hobbs, RFD, Martin, Ashley, Wilson, Sue, Dr, Redman, Valerie, Colbourne Lynne, Wakelam, MJ, Redman, Val. D., Colbourne, Lynne, Ryan, Angela V., Wilson Sue, Angela V Ryan, Ryan, AV, Tariq Ismail, Fiona Patrick, Ashley Martin, Richard FD Hobbs, Ryan Angela V, Patrick, Fiona, Patrick, F, Ismail, Tariq, Ismail Tariq, Dunn, Janet A., Wilson, Sue, Redman Val D, Ryan, Angela, Dunn Janet A, Wakelam, MJO, Hobbs, RF, Dunn, JA, Hobbs, Richard F. D., Patrick Fiona, Wakelam Michael JO   +46 more
core   +2 more sources

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

A Narrative Literature Review on Sepsis: A Primary Manifestation of Colorectal Neoplasm. [PDF]

Cureus, 2023
Masood L, Müller A, Ali NZ, Mummadisetty A, Yahya A, Burugu SS, Sajid R, Lakkimsetti M, Sagireddy S, Abdin ZU, Nazir Z.   +10 more
europepmc   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Appendiceal Mucocele Diagnosed in Patients with Inflammatory Bowel Disease Using Endoscopic Ultrasound

Case Reports in Medicine, 2012
When a bulging appendiceal orifice is observed during surveillance colonoscopy, the possibility of appendiceal mucocele must be considered. Appendiceal mucocele is a rare group of lesions characterized by mucinous distension of the appendiceal lumen with
Uni Wong, Peter Darwin
doaj   +1 more source

Increased colorectal cancer incidence in obligate carriers of heterozygous mutations in MUTYH

, 2002
Background & Aims: MUTYH-associated polyposis (MAP) is an autosomal recessive disorder caused by mutations in the MUTYH gene. Patients with MAP are at extremely high risk of colorectal cancer, but the risks of colorectal and other cancers in ...
Jones, Natalie, Maher, Eamonn, Sampson, Julian Roy, Edwards, Emma, Christian, Daria, Evans, D Gareth, Vasen, Hans F., Wark, Petra A., Sampson, Julian R, Eccles, Diana, Aretz, Stefan, Nielsen, Maartje, Maher, Eamonn R., Wark, Petra A, Vogt, Stefanie, Wark, Petra A.; id_orcid, Hes, Frederik J, Hes, Frederik J., Evans, D. Gareth, Sampson, Julian R., Vasen, Hans F, Maher, Eamonn R   +21 more
core   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source