Results 101 to 110 of about 855,584 (391)

Presence of Iron in Colorectal Adenomas and Adenocarcinomas

Gut and Liver, 2008
Background/Aims: Iron overload reportedly increases the risk of colorectal neoplasms, but the distribution of tissue iron in a colorectal neoplasm remains controversial.
doaj   +1 more source

Somatic mutations in the chromatin remodeling gene ARID1A occur in several tumor types [PDF]

, 2011
Mutations in the chromatin remodeling gene ARID1A have recently been identified in the majority of ovarian clear cell carcinomas (OCCCs). To determine the prevalence of mutations in other tumor types, we evaluated 759 malignant neoplasms including ...
Bigner, Darell, Eshleman, James R., Goggins, Michael, Hruban, Ralph H., Iacobuzio‐donahue, Christine A., Jones, Siân, Kinzler, Kenneth W., Kristel, Petra, Li, Meng, Maitra, Anirban, Malek, Sami N., Markowitz, Sanford, Papadopoulos, Nickolas, Parsons, D. Williams, Powell, Steve, Schmidt, Marjanka K., Velculescu, Victor E., Vogelstein, Bert, Wesseling, Jelle, Yan, Hai, Zhang, Xiaosong   +20 more
core   +1 more source

Addressing persistent challenges in digital image analysis of cancer tissue: resources developed from a hackathon

Molecular Oncology, EarlyView.
Large multidimensional digital images of cancer tissue are becoming prolific, but many challenges exist to automatically extract relevant information from them using computational tools. We describe publicly available resources that have been developed jointly by expert and non‐expert computational biologists working together during a virtual hackathon
Sandhya Prabhakaran, Clarence Yapp, Gregory J. Baker, Johanna Beyer, Young Hwan Chang, Allison L. Creason, Robert Krueger, Jeremy Muhlich, Nathan Heath Patterson, Kevin Sidak, Damir Sudar, Adam J. Taylor, Luke Ternes, Jakob Troidl, Xie Yubin, Artem Sokolov, Darren R. Tyson   +16 more
wiley   +1 more source

Estradiol regulates miR-135b and mismatch repair gene expressions via estrogen receptor-β in colorectal cells. [PDF]

, 2012
Estrogen has anti-colorectal cancer effects which are thought to be mediated by mismatch repair gene (MMR) activity. Estrogen receptor (ER) expression is associated with microRNA (miRNA) expression in ER-positive tumors.
Fu, Lei, He, Yu-qi, Jin, Peng, Ling, Xian-long, Rao, Jianyu, Sheng, Jian-qiu, Yen, Lawrence   +6 more
core   +1 more source

Targeted metabolomics reveals novel diagnostic biomarkers for colorectal cancer

Molecular Oncology, EarlyView.
This study employed targeted metabolomic profiling to identify 302 distinct metabolites present in platelet‐rich plasma (PRP), revealing aberrant metabolic profiles amongst individuals diagnosed with colorectal cancer (CRC). Compared to carcinoembryonic antigen (CEA) and cancer antigen 19‐9 (CA199), our metabolite panel showed improved sensitivity ...
Zuojian Hu, Fenglin Shen, Yang Liu, Ziqing Zhong, Yongling Chen, Zhiyuan Xia, Cuiju Mo, Hongxiu Yu   +7 more
wiley   +1 more source

MALIGNANCY IN LARGE COLORECTAL LESIONS

Arquivos de Gastroenterologia, 2014
Context The size of colorectal lesions, besides a risk factor for malignancy, is a predictor for deeper invasion Objectives To evaluate the malignancy of colorectal lesions ≥20 mm.
Carlos Eduardo Oliveira dos SANTOS, Daniele MALAMAN, Tiago dos Santos CARVALHO, César Vivian LOPES, Júlio Carlos PEREIRA-LIMA   +4 more
doaj   +1 more source

Physiopathological Implications of 7TM Receptors [PDF]

, 2010
Seven-transmembrane (7TM) receptors are one of the most important proteins involved in perception of extracellular stimuli and regulation of variety of intracellular signaling pathways.
Cygankiewicz, Adam
core   +1 more source

Anatomical distribution and detection rate of colorectal neoplasms according to age in the colonoscopic screening of a Korean population

Annals of Surgical Treatment and Research, 2017
Purpose Because data as a basis for the determination of proper age and modality for screening of colorectal neoplasms is lacking, we evaluated detection rates and anatomical distribution of colorectal neoplasms according to age in healthy individuals ...
Suk-Young Lee, W. Song, S. Oh, B. Min, S. Lee   +4 more
semanticscholar   +1 more source

Inhibition of acyl‐CoA synthetase long‐chain isozymes decreases multiple myeloma cell proliferation and causes mitochondrial dysfunction

Molecular Oncology, EarlyView.
Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy, Heather Fairfield, Victoria E. DeMambro, Samaa Fadel, Carlos A. Gartner, Michelle Karam, Christian Potts, Princess Rodriguez, Ya‐Wei Qiang, Habib Hamidi, Xiangnan Guan, Calvin P. H. Vary, Michaela R. Reagan   +12 more
wiley   +1 more source

Diagnostic Value of Stool Dna Testing for Multiple Markers Of Colorectal Cancer and Advanced Adenoma: A Meta-Analysis

Canadian Journal of Gastroenterology, 2013
BACKGROUND AND OBJECTIVES: The diagnostic value of stool DNA (sDNA) testing for colorectal neoplasms remains controversial. To compensate for the lack of large-scale unbiased population studies, a meta-analysis was performed to evaluate the diagnostic ...
Hua Yang, Bing-Qing Xia, Bo Jiang, Guozhen Wang, Yi-Peng Yang, Hao Chen, Bing-Sheng Li, An-Gao Xu, Yun-Bo Huang, Xin-Ying Wang   +9 more
doaj   +1 more source