Results 111 to 120 of about 79,443 (280)

Research progress and prospects of colored zirconia ceramics: A review

open access: yesJournal of Advanced Ceramics
Owing to their rich color, excellent mechanical properties, and favorable biocompatibility, colored zirconia ceramics have been widely used in intelligent terminals, dental restoration, colored decorations, and other potential fields.
Yudie Yang, Chen Hu, Qiang Liu, Jiang Li
doaj   +1 more source

Methodological Basis for the Formation of a Motivational Mechanism of Environmental Resource Management in Ukraine [PDF]

open access: yesProblemi Ekonomiki, 2017
The author’s definition, semantic and functional filling of the motivational mechanism for the implementation of the basic principles of environment-oriented managerial influence within the urbanized space is presented.
Khumarova Nina I. , Popyk Oleh V.
doaj  

Heat treatment optimization in Al-Cu-Mg-Si alloys, with or without prior deformation [PDF]

open access: yes, 2018
Asensio Lozano, Juan   +3 more
core   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

open access: yesMolecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski   +9 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

open access: yesFEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas   +6 more
wiley   +1 more source

Neural Mechanism of Color Vision

open access: yesThe Journal of the Institute of Television Engineers of Japan, 1975
色覚のYoung説, Hering説は, いま単一神経応答の中に捉えられている.その方法論と研究の現状をコイの網膜などの結果から紹介したが, 色覚は3錐体だけでなく, 継時色対比, 同時色対比の時空間的情報を伝えるcolor cellの存在ではじめて成立つことを強調している.ヒトの複雑な色彩感覚とか色盲などの今後の研究に新しい基礎になるものと思われる.
openaire   +2 more sources

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