Results 71 to 80 of about 79,443 (280)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Investigation on the Coloring Mechanism of Freshwater Cultured Pearls with Different Color

Yankuang ceshi, 2013
The coloring mechanism of pearls was debated on organic pigment or trace metal ions. In view of the theory of the coloring mechanism from organic pigment, which had no relationship with the structure of the object combined with the results of the trace ...
YAN Jun, HU Xian-chao, WANG Ju-an, YAN Xue-jun, HU Dan-jing, LIU Pei-jun, FANG Shi-bin   +6 more
doaj  

How flow and mindfulness interact with each other in mindfulness-based augmented reality mandala coloring activities

Frontiers in Psychology
IntroductionThis study explores the effects of different types of augmented reality (AR) mandala coloring activities on mindfulness and flow in college students.MethodsA total of 76 college students participated in the study and were divided into two ...
Hao Chen, Hao Chen, Chao Liu, Chao Liu, Ayuan Zhang, Wen-Qian Lu, Kan Wu, Wen-Ko Chiou, Wen-Ko Chiou, Wen-Ko Chiou   +9 more
doaj   +1 more source

Lowest common ancestor interconnection networks [PDF]

, 1992
Lowest Common Ancestor (LCA) networks are built using switches capable of connecting u + d inputs/outputs in a permutation pattern. For n source nodes and I stages of switches, n/d switches are used in stage l - n/d - u/d in stage l - 2, and in general ,
Alleyne, Brian D., Chien, Chi-Kai, Scherson, Isaac D.   +2 more
core  

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Metabolomic and Transcriptomic Analysis of the Mechanism of the Apple Coloration Change After Uncovering Fruit Bag

International Journal of Fruit Science
Coloring is an important external quality of apples. Commercial apple varieties are bagged before the fruits ripen to ensure they grow in a pesticide-free environment, including preventing mechanical damage, reducing sunburn, etc.
Pengwei Duan, Xiaojian Ma, Haiqiang Shi, Lizhe Qin, Jizhuang Du, Sumiao Yang, Jianjun Zhang   +6 more
doaj   +1 more source

Statistical mechanics of colored objects [PDF]

Physics Letters B, 2000
Abstract A microscopic model of deconfined matter based on color interactions between quarks is studied. A hadronization mechanism is imposed to examine the properties and the disassembly of a thermalized quark plasma and to investigate the possible existence of a phase transition from quark matter to hadron matter.
M. Hofmann, M. Bleicher, S. Scherer, L. Neise, H. Stöcker, W. Greiner   +5 more
openaire   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source