Results 111 to 120 of about 4,730,209 (296)

Stability of slender columns on an elastic foundation with generalised end conditions

open access: yesIngeniería e Investigación, 2013
Slender columns’ lateral stability under compressive axial loads is presented, with uninhibited, partially inhibited and totally inhibited end side-sway, including the effects of semi-rigid connections and a uniformly distributed lateral elastic ...
J. Dario Aristizabal-Ochoa
doaj  

Ductility of Eccentrically Compressed Elements of RC Frame Damaged by Corrosion under Accidental Impacts

open access: yesЖелезобетонные конструкции, 2023
The impact of aggressive environments and, accordingly, the corrosion damage of concrete and reinforcing steel, the violation of adhesion between them in some areas lead to a change in the values of the limiting height of the compressed zone, which ...
S. Yu. Savin   +2 more
doaj  

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

open access: yesMolecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris   +10 more
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon   +9 more
wiley   +1 more source

Two Early Palindromic Peoms by Caliban [PDF]

open access: yes, 2005
Hubert Phillips, English crossword puzzle and logic puzzle constructor, created at least two palindromic poems. The first one was featured in Bergerson\u27s Palindromes and Anagrams (page 94); it originally appeared in the Dogberry column in the London ...
Michaelsen, Ove
core   +1 more source

The influence of the beam-column connection on the global results of multi-storey reinforced concrete structures

open access: yesRevista IBRACON de Estruturas e Materiais
The effect of the semi-rigid connection between beams and columns on the global behavior of reinforced concrete (RC) structures was investigated. The relative rotations in the nodes of the spatial frames were determined using the analytical approach ...
Lucas Manoel   +2 more
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

open access: yesMolecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal   +4 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

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