Results 91 to 100 of about 633,372 (303)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Post-fire performance evaluation of steel connections under a column-loss scenario
Developments in the Built EnvironmentThis study evaluates the post-fire performance of steel connections under a column-loss scenario. A series of fire tests, coupon tests and cyclic loading tests were carried out on 5 sets of 1/3-scaled SN400YB steel H-beam-to-H-column connections.
Heui-Yung Chang +3 more
doaj +1 more source
Structural performance of semi-rigid composite frame under column loss [PDF]
, 2015 The catenary action associated with significant second order effects plays an important role in resisting additional loads when structural column is destroyed under unexpected loads.
Fu, F., Guo, L., Gao, S.
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Integrated Nano Liquid Chromatography System On-a-Chip [PDF]
, 2006 Integrated liquid chromatography (LC) chips are valued because of their significant advantages over conventional systems. However, they are very challenging to build due to the high complexity of LC systems and the need for high-level integration of many
He, Qing
core +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Reinforced Concrete Beam-Column Inverted Knee Joint Behaviour after Ground Corner Column Loss-Numerical Analysis [PDF]
, 2018 Beam-column joints are critical component in the load path of reinforced concrete (RC) frames, due to their role in transferring loads among different RC frame components.
B. Abdelwahed (5836004) +2 more
core +3 more sources
Beam-Column Joints Reinforcement Detailing Adequacy in Case of a Corner Column Loss-Numerical Analysis [PDF]
, 2019 This study investigates the behavior of reinforced concrete (RC) beam-column joints at the corner panel after a ground corner column loss scenario.
B. Abdelwahed (5836004)
core +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
A New Batch Extractive Distillation Operational Policy for Methanol Recovery
Chemical Engineering Transactions, 2013 The recovery of methanol from a multicomponent aqueous waste solvent mixture was studied. The components form several minimum azeotropes, of which the methanol-THF and methanol-toluene azeotropes limit the recovery of methanol by traditional batch ...
L. Hegely, P. Lang, G. Kovacs
doaj +1 more source