Results 101 to 110 of about 633,372 (303)

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Experimental Study on Progressive Collapse Performance of RC Flat Plate Structures in the Scenario of Side Column Loss

工程科学与技术, 2019
Two 1/3.5 reduced scale one-story 1 × 2 bay reinforced concrete (RC) flat plate sub-structures were fabricated and static progressive collapse tests in the scenario of a side column loss were carried out on them.
Tao YANG, Jinming LIAN, Xide ZHANG
doaj  

Alternate load paths in mitigating progressive collapse of RC building structures subjected to column loss scenarios [PDF]

, 2010
Column loss scenarios result in high potential for progressive collapse of RC building structures since the gravity loads are severely amplified by both doubling-of-span and dynamic factors.
Tan, Kang Hai, Pham, Xuan Dat, Yu, Jun
core  

Robustness assessment of a steel self-centering moment-resisting frame under column loss [PDF]

, 2018
The robustness of a seismically-designed steel self-centering moment-resisting frame (SCMRF) under a column loss scenario is numerically assessed. The prototype SC-MRF is equipped with post-tensioned bars and optimised stainless steel energy dissipation
Vasdravellis, George; id_orcid, Marco Baiguera, George Vasdravellis, Baiguera, M, Al-Sammaraie, D, Vasdravellis, G, Al-Sammaraie, Dina, Dina Al-Sammaraie, Baiguera, Marco   +8 more
core   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Assessment for the Progressive Collapse of Moment Resisting Frame Structures Using a Practiced-Oriented Method

ASM Science Journal, 2018
Abnormal loads that include explosions, vehicle accidents, bombings and earthquakes that cause column failure may lead to progressive collapse. This study investigated the potential of progressive collapse of column removal in order to evaluate the ...
shahiron shahidan
doaj  

Innovative Retrofitting for Disaster Resilience: Optimizing Steel Plate Grade and Scheme in RC Non-Seismic Frames to Prevent Progressive Collapse

Buildings
Reinforced concrete (RC) non-seismic frames in Middle Eastern multistory buildings often have beam–column connections with discontinuous bottom reinforcement, heightening the risk of progressive collapse if an outer column fails.
Hussein M. Elsanadedy, Tarek H. Almusallam, Husain Abbas, Yousef A. Al-Salloum   +3 more
doaj   +1 more source