Results 91 to 100 of about 2,566,141 (344)

Emergence of physiological oscillation frequencies in a computer model of neocortex

open access: yesFrontiers in Computational Neuroscience, 2011
Coordination of neocortical oscillations has been hypothesized to underlie the binding essential to cognitive function. However, the mechanisms that generate neocortical oscillations in physiological frequency bands remain unknown.
Samuel A Neymotin   +11 more
doaj   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

open access: yesMolecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris   +10 more
wiley   +1 more source

Performance Evaluation of Reinforced Recycled Aggregate Concrete Columns under Cyclic Loadings

open access: yesApplied Sciences, 2019
Recycled concrete aggregates (RCAs) generated from construction and demolition activities have been recognized as a feasible alternative to natural aggregates (NAs).
Fan Wang   +5 more
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon   +9 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

Mesoscale functional organization and connectivity of color, disparity, and naturalistic texture in human second visual area

open access: yeseLife
Although parallel processing has been extensively studied in the low-level geniculostriate pathway and the high-level dorsal and ventral visual streams, less is known at the intermediate-level visual areas. In this study, we employed high-resolution fMRI
Hailin Ai   +4 more
doaj   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

open access: yesMolecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal   +4 more
wiley   +1 more source

Parametric Study on the Buckling of Unbraced Steel Frames under Fire Situation

open access: yesApplied Sciences
A parametric investigation of several unbraced steel frames with regular and irregular geometry subjected to elevated temperatures is carried out in this study to determine the most accurate procedure and buckling lengths to be considered during the ...
Thiago Silva   +3 more
doaj   +1 more source

Automatic Detection and Segmentation of Columns in As-Built Buildings from Point Clouds

open access: yesRemote Sensing, 2015
Over the past few years, there has been an increasing need for tools that automate the processing of as-built 3D laser scanner data. Given that a fast and active dimensional analysis of constructive components is essential for construction monitoring ...
Lucía Díaz-Vilariño   +3 more
doaj   +1 more source

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