Results 71 to 80 of about 2,385,032 (294)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Monotonic and Cyclic Seismic Analyses of Old-Type RC Columns with Short Lap Splices

Construction Materials
Reinforced concrete (RC) columns with short lap splices built in the early 1970s or before are known to have deficient seismic strength and ductility. These short lap splices are poorly confined and located right above the foundation level, where it is ...
Konstantinos G. Megalooikonomou
doaj   +1 more source

Column Chromatography [PDF]

Current Protocols in Nucleic Acid Chemistry, 2000
AbstractColumn chromatography is used extensively in nucleic acid chemistry to purify or characterize products from chemical reactions. This appendix focuses on separations using silica gel or alumina. The procedures described include loading the column, assembling the apparatus, separating compounds and collecting fractions, and optimizing ...
openaire   +3 more sources

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The full-scale test of bearing structures of the shelter to assess the possibility of its further operation

Budownictwo i Architektura
Today, military operations continue in Ukraine, and the need for protective structures is increasing. The scientific work describes the structural scheme of the existing shelter, including the determination of cross-sectional dimensions, thicknesses ...
Andrii Kramarchuk, Borys Ilnytskyy , Oksana Lytvyniak   +2 more
doaj   +1 more source

Nonlinear analysis of lightweight aggregate concrete columns

Budownictwo i Architektura, 2020
The paper presents a numerical analysis of deformability and load-bearing capacity of lightweight aggregate concrete (LWAC) elements subjected to bending with axial force.
Ewelina Kołodziejczyk, Tomasz Waśniewski   +1 more
doaj   +1 more source

Stratigraphic columns and correlations for the Late Eocene - Oligocene Te Kuiti Group, central-western North Island, New Zealand [PDF]

, 2008
This report presents a compilation of stratigraphic columns for geological sections and outcrops of Late Eocene – Oligocene Te Kuiti Group units in central-western parts of North Island, New Zealand, between Port Waikato and Awakino.
Kamp, Peter J.J., Nelson, Campbell S., Tripathi, Anand Ratnakar Prasad   +2 more
core   +1 more source

Correlated and Decorrelated Positional and Orientational Order in the Nucleosomal Core Particle Mesophases

, 2004
We investigate the orientational order of transverse polarization vectors of long columns of nucleosomal core particles and their coupling to positional order in high density mesophases discovered recently.
Lorman, V., Podgornik, R., Žekš, B.
core   +3 more sources