Results 101 to 110 of about 3,195,529 (338)
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
eLifeAlthough parallel processing has been extensively studied in the low-level geniculostriate pathway and the high-level dorsal and ventral visual streams, less is known at the intermediate-level visual areas. In this study, we employed high-resolution fMRI
Hailin Ai +4 more
doaj +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Parametric Study on the Buckling of Unbraced Steel Frames under Fire Situation
Applied SciencesA parametric investigation of several unbraced steel frames with regular and irregular geometry subjected to elevated temperatures is carried out in this study to determine the most accurate procedure and buckling lengths to be considered during the ...
Thiago Silva +3 more
doaj +1 more source
Automatic Detection and Segmentation of Columns in As-Built Buildings from Point Clouds
Remote Sensing, 2015 Over the past few years, there has been an increasing need for tools that automate the processing of as-built 3D laser scanner data. Given that a fast and active dimensional analysis of constructive components is essential for construction monitoring ...
Lucía Díaz-Vilariño +3 more
doaj +1 more source
Covalent bonding of antibodies of polystyrene latex beads: A concept [PDF]
, 1972 Technique facilitates purification of vaccines and production of immunoadsorption columns exhibiting relatively long stability.
Smith, D. G., Tenoso, H. J.
core +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Experimental Investigation of the Confinement of Concrete Columns with Welded Wire Reinforcement
BuildingsTraditional methods of construction for reinforced concrete columns utilize longitudinal steel bars and transverse ties. Field experience has shown that such a transverse reinforcement method is labor-intensive, time-consuming, and prone to ...
Abdelaziz Younes, Sami W. Tabsh
doaj +1 more source
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source