Results 71 to 80 of about 3,564,000 (279)

Healthcare providers perspectives on HIV-NCD integration to Meet the needs of older adults living with HIV

BMC Geriatrics
Background Advances in antiretroviral therapy have enabled people living with HIV (PLHIV) to live longer and healthier lives. However, aging with HIV infection is accompanied by an increased risk of non-communicable diseases (NCDs), highlighting the need
Jepchirchir Kiplagat, Violet Naanyu, Jemimah Kamano, Rajesh Vedanthan, Sonak Pastakia, Kara Wools-Kaloustian   +5 more
doaj   +1 more source

Compliant Pneumatic Feet with Real‐Time Stiffness Adaptation for Humanoid Locomotion

Advanced Robotics Research, EarlyView.
A compliant pneumatic foot with real‐time variable stiffness enables humanoid robots to adapt to changing terrains. Using onboard vision and pressure control, the foot modulates stiffness within each gait cycle, reducing impact forces and improving balance. The design, cast in soft silicone with embedded air chambers and Kevlar wrapping, offers durable,
Irene Frizza, Hiroshi Kaminaga, Philippe Fraisse, Gentiane Venture   +3 more
wiley   +1 more source

Barriers and Facilitators to Antimicrobial Stewardship in Antibiotic Prescribing and Dispensing by General Practitioners and Pharmacists in Malta: A Systematic Review

Antibiotics
Objective: Antimicrobial resistance (AMR) is a top ten threat to global public health, and Malta remains among the highest antibiotic-consuming countries in the European Union.
Brian Fenech, Daniel Gaffiero
doaj   +1 more source

β‐Elemene Rescues Radiation‐Induced Enteritis by Orchestrating a Host‐Microbiome Circuit That Fuels Epigenetic DNA Repair

Advanced Science, EarlyView.
This study elucidates that β‐elemene promotes cellular uptake of L. gasseri‐derived lactate by enhancing the membrane translocation of MCT1 in a CD147‐dependent manner. Intracellular lactate, through the lactylation of RBBP4 at the K26 site, recruits EP300 to the promoter regions of downstream genes (POLD1/POLD3), catalyzing H3K27ac modification.
Jiancheng He, Jiapeng Bao, Shukang Deng, Weijie Zang, Haoming Yan, Zihao Zhao, Guangze Zhang, Ruiqing Liu, Junjie Chen, Yilin Hu, Wanjiang Xue   +10 more
wiley   +1 more source

Pharmacologic Modulation of ARID3A with Rimegepant Reactivates Type I Interferon Signaling and Sensitizes Triple‐Negative Breast Cancer to PD‐1 Blockade

Advanced Science, EarlyView.
This study identifies ARID3A as a key immunosuppressive transcription factor in TNBC. Its inhibition activates the type I IFN pathway, boosting CD8+ T cell infiltration and sensitizing tumors to anti‐PD‐1. The FDA‐approved migraine drug Rimegepant targets ARID3A, enhances immunotherapy efficacy in preclinical models, and establishes a druggable axis to
Teng Zhou, Yifei Zhu, Cheng Zeng, Jinlu Han, Huiying Huang, Doudou Li, Mingxi Lin, Yizi Jin, Qin Guo, Yuxin Yan, Xinhui Mao, Yifei Zhou, Jian Zhang   +12 more
wiley   +1 more source

The COM-B model.

, 2019
The COM-B model.
Chisom Obiezu-Umeh (6391874), Juliet Iwelunmor (770171), David Oladele (6807962), Joyce Gyamfi (3293661), Angela Aifah (3805093), Oliver Ezechi (6807953), Adesola Z. Musa (6807959), Ifeoma Idigbe (6807965), Babatunde Salako (164142), Titilola Gbajabiamila (6807956), Aigbe Ohihoin (6807968), Olugbenga Ogedegbe (770174)   +11 more
core   +1 more source

Pro-Environmental Transformation of the Equine Sector—Facilitators and Challenges

Animals
To improve horse welfare and ensure a sustainable equestrian future, we need to understand human behavior in relation to the challenges of the sector. The purpose of this paper is to map and analyze how individuals within the equine sector in Sweden and ...
Susanna Hedenborg, Mathilde Kronborg, Anna Sätre, Aage Radmann, Gabriella Torell Palmquist, Petra Andersson   +5 more
doaj   +1 more source

Endogenous Engineering Reprograms Extracellular Vesicles for Enhanced Therapeutic Function

Advanced Science, EarlyView.
This review explains how Extracellular vesicles‐producing cells can be endogenously engineered to load therapeutic proteins and nucleic acids. We summarize physiological and genetic strategies that harness native sorting pathways for selective cargo loading.
Jinghui Wang, Wenxuan Zhao, Xiaoming Hu, Yishu Wang, Peidong Yang, Diwei Zheng, Yugang Wang, Guanghui Ma, Min Shi, Wei Wei, Shuang Wang   +10 more
wiley   +1 more source

Online Gaming and Healthy Lifestyles: A Qualitative Study of Gamers in Saudi Arabia

Societies
Gamers and esports players encounter distinct health challenges that can affect their well-being and performance. Recognising these needs is crucial for developing effective health interventions.
Yara Almuhtadi, Samah Alageel
doaj   +1 more source

Efficient Electrocatalytic Conversion of CO2 to Pure Formic Acid Solutions via Strain‐Engineered Bismuth Nanosheets

Advanced Science, EarlyView.
Tensile‐strained bismuth nanosheets (TS‐BiNs) achieve a formate Faradaic efficiency of 92% at −1000 mA cm−2 and enable stable production of pure formic acid (HCOOH) in a solid‐state electrolyte reactor. Theoretical calculations reveal that the introduced strain lowers the energy barrier for *OCHO intermediate formation, fundamentally enhancing the ...
Shiqi Li, Yuefeng Zhang, Panzhe Qiao, Cuo Wu, Xinya Tian, Yufeng Xu, Yun Zhang, Peng Wang, Tingting Li, Muhammad Afaq, Xinlin Luo, Tang Wang, Chunxiao Liu, Zi‐You Yu, Chuan Xia, Min‐Rui Gao, Zhen‐Yu Wu   +16 more
wiley   +1 more source