Results 191 to 200 of about 159,503 (247)

VSED Should Not Be a Pathway to MAiD (Though Both Are Ethically Permissible)

open access: yesBioethics, EarlyView.
ABSTRACT Recent changes in aid in dying laws have led some to argue for a pathway from Voluntarily Stopping Eating and Drinking (VSED) to Medical Aid in Dying (MAiD). Proponents point to the Sontag case as demonstrating the efficacy of the practice. This article first provides an overview of the development of the practice of VSED and MAiD and provides
D. B. Davison
wiley   +1 more source

ReMoDe – Recursive modality detection in distributions of ordinal data

open access: yesBritish Journal of Mathematical and Statistical Psychology, EarlyView.
Abstract The detection of the number of modes in distributions of ordinal data is relevant for applied researchers across disciplines, from uncovering polarization to detecting incidence groups in clinical symptom scales. Yet, established modality detection methods are either purely descriptive or not developed for ordinal data.
Madlen Hoffstadt   +3 more
wiley   +1 more source

Targeting KRAS for cancer therapy

open access: yesBritish Journal of Pharmacology, EarlyView.
In recent years, therapeutics targeted against KRAS proto‐oncogene GTPase (KRAS)‐mutant cancers have seen significant progress. Herein we outline the biology and epidemiology of KRAS alterations at the lineage and allele levels, reviewing the clinical evidence for KRASG12C inhibition from the discovery of the recessive switch pocket to sotorasib ...
Jianlong Jia   +4 more
wiley   +1 more source

Re‐thinking peripheral dysfunctions in obesity: The emerging role of sulphaceutics and sulphanutraceutics

open access: yesBritish Journal of Pharmacology, EarlyView.
Obesity is a chronic, relapsing, multisystem disease in which cardiometabolic risk arises from excess adiposity and progressive dysfunction of peripheral organs, ultimately disrupting endocrine and metabolic crosstalk among tissues. Within this network, sulphur‐based biology, centred on hydrogen sulphide and related reactive sulphur species, has ...
Martina Smimmo   +4 more
wiley   +1 more source

Stepwise clinical and diagnostic strategy for coma of unknown origin. [PDF]

open access: yesIntensive Care Med
Silva S   +8 more
europepmc   +1 more source

Non‐Rigid 3D Shape Correspondences: From Foundations to Open Challenges and Opportunities

open access: yesComputer Graphics Forum, EarlyView.
Abstract Estimating correspondences between deformed shape instances is a long‐standing problem in computer graphics; numerous applications, from texture transfer to statistical modelling, rely on recovering an accurate correspondence map. Many methods have thus been proposed to tackle this challenging problem from varying perspectives, depending on ...
A. Zhuravlev   +14 more
wiley   +1 more source

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