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Effect of intensive care unit sedation strategy on patient‐reported experience: secondary mediation analysis of the A2B randomised controlled trial
Anaesthesia, EarlyView.Summary Introduction
The optimal ICU sedation strategy to improve patient‐reported experience is unknown. In a planned secondary analysis of the A2B randomised trial, we evaluated the effect of sedation strategy (dexmedetomidine, clonidine or propofol) on recalled patient experience at 90 days post‐randomisation.John A. Masterson, Isabella Ritchie, Leanne M. Aitken, Bronagh Blackwood, Kalliopi Kydonaki, Cathrine A. McKenzie, Richard A. Parker, Christopher J. Weir, Timothy S. Walsh, Nazir I. Lone, on behalf of the A2B trial investigators, Natalie Pattison, Barry Williams, Louise Rose, Paul Mouncey, John Prowle, David Wellsted, Tim Walsh, Stephen Brett, Heather Charles, Christoper Weir, John Norrie, Julian Bion, Graeme McLennan, Matt Stevenson, Alistair Nichol, Timothy Walsh, Maria Amamio, Lucy Barclay, Sophie Birch, Kate Briton, Sarah Clark, Jessica Crossan, Katherine Doverman, David Hope, Lucy Macdonald, Corrienne McCulloch, Nicola Rae, Scott Simpson, Jo Singleton, Maggie Wishart, Ruth Thompson, Neill Aitken, Rachel Fairlie, Nabeel Salim, Sam Talbot, Sarah Ackroyd, Valeria Alicino, Euan Allan, Thomas Anderson, Rosemary Andrew, Andrew Baigey, Kenneth Baillie, Calum Barnetson, Ruth Begbie, Richie Biggers, Michael Blaney, Richard Broom, David Birrell, Will Calkin, Keegan Chuavilong, Rebecca Cowden, Thomas Cox, Coral Darjee, Simon Davies, Annemarie Docherty, Luke Dornan, Mark Dunn, Stuart Edwardson, Ross Gillespie, Jane Greenwood, David Griffith, Alasdair Hay, Amy Hu, Ali Hunter, Karen Jones, Helen Jordan, Ancy Joseph, Kallirroi Kefala, Stephanie Kelly, Laura Kemp, Bara Kubanova, Victoria Leng, John Livesey, Nazir Lone, James Lyon, Olivia Mansfield, Dean McAvoy, Aaron McClatchey, Jonathan Miller, Ananda Mirchandani, Peter Moffitt, Steven Morrison, Alexandra Muir, Kieran Nunn, John Ochiltree, Emily Ogden, Matthew Parks, Marc Pass, Rachael Penrose, Harry Putnam, Thomas Quinn, Jonathan Rhodes, Alexander Rollings, Stephen Ross, Ralph Shackleton, Manu Shankar, Sunil Sharma, Iain Slessor, Zack Slevin, Duncan Stickle, Louise Symons, Fiona Walker, Luke Walls, Ian Whiteford, Sue Yin Yong, Neil Young, Kevin Rooney, Michael Kinsella, Brian Digby, Michael Brett, Paul McConnell, Mark Henderson, Radha Sundaram, Lisa Gemmell, Fiona Christie, Philip Henderson, Fiona MacGregor, Steven Henderson, Natalie Rodden, Kirsty Fallon, Lynn Abel, Barbara McLaren, Emma Hughes, Deborah McGlynn, Nicola Thomson, Lauren Walker, Susan Currie, Natasha Parker, Donna Gillan, Farooq Brohi, Sarah Purvis, Michele Clark, Pam Race, Lynne Williams, Ahmed Shahin, Eusebius Nworah, Jonathan Gui, Li‐Chin Cheng, Katelyn Stewart, Rebecca Cusack, Mark Tomlin, Clare Bolger, Rachel Burnish, Sue Jackson, Alice Baker, Jonathan Biss, Karen Salmon, Michael Carter, Catherine McKenzie, Razaz Elsheikh, Missy (Anne) Harrison, Charlotte Thomas, James Ward, Andrew Cumpstey, Ahilanandan Dushianthan, Ivan Kemp, Valerie Page, Xiaobei Zhao, Nazril Nordin, Ahmed Hegazy, Elvira Hoxha, Owen Hardaker, Chimenime Ede, Nailia Kotrikova, Acharya Devaraja, Thomas Stambach, Prasun Mukherjee, Mark Louie Guanco, Matthew P Wise, Jade Cole, Helen Hill, Jenny Brooks, Michelle Davies, Rhys Davies, Emma Thomas, Angharad Williams, Lauren Lodhi, Matt PG Morgan, Simon Ridler, Christopher Smith, Maria Faulkner, Alison Ivison, Laura McKay, Helen Jeffrey, Jude Price, Lucy Slater, Angela Davies, Edward Hughes, Matt Thomas, Dominic Janssen, Ian Thomas, Kate Crewdson, Christopher Newell, Robert Hirst, Stephen West, Agnieszka Skorko, Emma Gendall, Ruth Worner, Beverley Faulkner, Borislava Borislavova, Kati Hayes, Andrew Parsons, Elizabeth Goff, John Sowersby, Annie Wood, Kieran Oglesby, Idrisu Sanusi, Charlie Pope, Andrew Baird, Hayley Blackmore, Robert Healey, Philip Hopkins, Eleanor Corcoran, Gillian Selman, Clare Finney, Evita Pappa, John Smith, Emma Clarey, Maeve Cockrell, Sian Saha, Harriet Noble, Kevin O'Reilly, Maria Depante, Anna Broderick, Marianette Anne Axalan, Burt Vergara, Reena Mehta, Henrik Reschrieter, Sarah Patch, Julie Camsooksai, Sarah Jenkins, Madga Pomichowska, Ken Power, Spike Briggs, Elizabeth Woodward, Christopher Loew, James Bromilow, James Keegan, Matthew Taylor, Emma Langridge, Dinesh Kulandhaisamy, Saah Savage, Yasmin de'Ath, Charlotte Humphrey, Sue Roffe, Matthew Bayliss, Leanne Bartlett, Richard Gordon‐Williams, Kate Tatham, Sam Smith, Isabel Noris, Sharjeel Tahir, Emma Yates, Shivali Patel, Tanith Westerman, Sekina Bakare, Hugh Furness, Emma Hunt, Reyhaneh Sadegh Zadeh, Maria Khan, William Sherwood, Claudio Addari, Roshni Manex, Nicole Whitehead, Fred Wilson, Luke Edwards, Kshiteeja Nalk, Sophie Biddle, Suzannah Lant, Francesca Holden, Shree Voralia, Nicola Ocean, Arun Sahni, Prakhar Srilastava, Sultan Iqbal, Shamil Tana, Vishal Venkat Raman, Zoszka Webb, Luke Parker, Arnold Dela Rosa, Miran Kadr, Eleanor Harvey, Ryan Howle, Aatif Husain, Olivia Morley, Sarah Loftus, Jenna Hutchinson, Shaman Jhanji, Ethel Black, David Parkinson, Ravishankar Raobaikady, Mark Borthwick, Christie James, Grace Polley, Neil Davidson, Sally Beer, Paula Hutton, Archana Bashyal, Jean Wilson, Soyamol Mathew, Jung Ryu, Jason Cupitt, Gareth Hardy, Leonie Benham, Robert Downes, Neil Flint, Michael Little, Ravindra Pochiraju, Prematie Andreou, Dawn Hales, Jessica Hailstone, Megha Mathews, Martin Huntley, Lorraine Stephenson, Jacqui Hussey, Hao‐Ern Tan, Simon Holbrook, Hayley Kemp, David Earl, Richard Innes, Benjamin Plumb, Patricia Doble, Rebecca Purnell, Ashly Thomas, Muhammad Hamza Noor, Waqas Khaliq, Micheal Jennings, Bernd Oliver Rose, Rosaleeta Reece‐Anthony, Sagira Khatun, Samantha Dickinson, Jayson Clarke, Charlie Cox, Adam Longley, Tariq Ali, Babita Gurung, Mohamed Moubarak, Alan Williams, Jonathan Ball, Susannah Leaver, Sarah Farnell‐Ward, Maria Thanasi, Shreeja Dangol, Vince Ventura, Massimiliano Valcher, Christine Sicat, Nikki Yun, Rebecca Kanu, Maria Maiz Cordoba, Ha Trinh, Karen Lloyd, Romina Pepermans Saluzzio, Lijun Ding, Helen Farrah, Edna Fernandes, Chris Nutt, Jon Silversides, Danny McAuley, Peter McGuigan, Emmet Major, Elliott Lonsdale, Nerielle Fundano, Kathryn Ward, Christine Turley, Aisling O'Neill, Stephanie Finn, Jackie Green, Erin Collins, Julie McAuley, Jeanette Mills, Chris Wright, Michelle Growcott, Iain McCullagh, Stephen Wright, Ian Clement, Jonathan Shelton, Matthew Faulds, Thomas Hellyer, Harriet Morton, Christopher Pollard, Christopher White, Leigh Dunn, Verity Calder, Susan Taylor, Pamela Garcia, Benjamin Brown, James Savage, Maite Babio‐Galan, Kimberley Webster, Tessa Wilkinson, Arti Gulati, Tara Shrestha, Carole Hays, Lauren Butler, Fatima Simoes, Margaret McNeil, Ian Storey, Simon Whiteley, Elizabeth Wilby, Susan Trott, Sarah Watts, Shailamma Mathew, Sheila Salada, Adam Neep, Nora Youngs, Clare Howcroft, Matthew Powell, Michael Adlam, Elankumaran Paramasivam, Zoe Friar, David Antcliffe, Stephen Brett, Anthony Gordon, Dorota Banach, Roceld Rojo, Sonia Sousa Arias, Ziortza Fernandez de Pinedo Artaraz, Phoebe Coghlan, Amal Mohammed, Eleanor Jepson, Jenny Wong, Anita Tamang Gurung, Caoimhe O'Dwyer, Sara Perez Guillotin, Maie Templeton, James Hanison, Jonathan Bannard‐Smith, Daniel Conway, Shoneen Abbas, Mohamad Aly, Stephen Benington, Teh Eng Hean, Daniel Hayley, Ellen McGuckin, Andrew Martin, Thomas Morris, William Musselbrook, Bhaskar Narayan, Thomas Wright, Chris Wheeler, Melanie Barker, Richard Clark, Emma Connaughton, Rose Jama, Deborah Paripoorani, Rachael Quayle, Anila Sukumaran, Charlotte Taylor, Megan Balmer, Saejohn Lingeswaran, Lauren Edmunds, Katharine Wylie, Andrew Owen, Gavin Perkins, Sean Munnelly, Daniel Park, Jo Gresty, Ellie Reeves, Celina Maliaykal, Teresa Melody, Jacobus Preller, Petra Polgarova, Cristina Bravoelvira, Sofia Teixeira, James Varley, Sapna Sharma Hajela, Kay Elston, Siobhan Campbell, Meike Keil, Muhammad Elbehery, Jocelyn Marshall, Susan Stevenson, Andrew Conway Morris, Prasad Gogineni Venkateskara, Michael Reay, Karen Reid, Rebecca Brown, Chinenyenwa Amareihe, Elliot Yates, Jia Luen Goh, Edward Jones, Aamer Mughal, David Brealey, Niall MacCallum, Samuel Clark, Deborah Smyth, Georgia Bercades, Ingrid Hass, Gladys Martir, Jung Ryu, Anna Reyes, Maria Alexandra Zapata Martinez, Laura Gallagher, Chi Yee Chung, Graeme Sanders, Vipal Chawla, Namrata Maheshwari, Tessa Glazebrook, Hollie Angel, Rebecca Squires, Hayley Dolan, Christopher Donnelly, Lucy Mires, Robert Musalagani, Suzanne Williams, Robin Heij, Peter Young, Mark Blunt, Gayathri Wijewardena, John Gibson, Aricsa Mariya Joshy, Jeremy Bewley, Kieron Rooney, Katie Sweet, Kim Wright, Lisa Grimmer, Denise Webster, Casandra Bazan Lacerot, Rachel Shiel, Eva Maria Hernandez Morano, Christina Coleman, Eleanor Daniel, Oluwatosin Komolafe, Josephine Bonnici, Linda Pipira, Rebekah Johnson, Anna Chillingworth, Ya‐Hui Liang, Georgia Efford, Angeliki Kolovou, George Davies, Zoe Garland, Bethany Gumbrill, Ivan Collin, Matthew Gibbins, Thomas Brougham, Agnieszka Skorko, Dan Harvey, William Phipps, Kathryn Harrold, Nick Plummer, Ben Lowe, Paul James, Sara Ahmed, Rukmini Ghosh, Omer Mohamed, Tanushree Santra, James Shilston, Andrew Russell, Viresh Patel, Upasana Topiwala, Habideen Bello, Julia Sampson, Lucy Ryan, Cecilia Peters, Megan Meredith, Louise Conner, Lucy Morris, Amy Clark, Alice Baddeley, Lisa Mcloughlin, Cate Walton, Treesa Joseph, Anju Thomas, Sophie Lubbock, David Ford, Alexandra McCoy, Tony N'Dungu, Ingeborg Welters, Vinoth Sankar, Alicia Waite, Brian Johnston, David Shaw, Vicki Waugh, Karen Williams, Maria Lopez Martinez, Maria Norris, Maria Arra Carlota Mahiya, Jamie Fernandez Roman, Jin‐Xi. Yuan, Silvia Manes, Caitlin Lythgoe, Ibrahim Almafreji, Josh Colfar, Laura Medhurst, Stephanie Beresford, Sofia Farina, Lema Imam, Syamlam Ali, Zachary Thomas, Francesca Bold, Edward Hughes, Katherine Hodson, Aleem Morenikeji, Daniel Watkin, Tamas Szakmany, Amy Cardwell, Anne Frawley, Marlies Ostermann, Gillian Radcliffe, Nicholas Barrett, Simon Sparkes, Adam Woodman‐Bailey, Eirini Kosifidou, Aneta Bociek, Ellie Hendrie, Rosario Lim, Fabiola D'Amato, Sarah Fordyce, Benjie Cendreda, Kyma Morera Vas, Jacqueline Pan, Christopher Meddings, Vladimir Milic, Mike Barker, Jennifer Owusu‐Afriyie, Carolin Engelhard, Malcolm Sim, Richard Appleton, Maximilian Ralston, Andrew Arnott, Steven Henderson, Izabela Orlikowska, Sophie Kennedy‐Hay, Christopher Murray, Matthew Devine, Padraig Headley, John McCaffrey, Daniel Donnelly, Richard Young, Samantha Hagan, Victoria Adell, Elizabeth Murphy, Alasdair Hay, Jian Quek, Stephen Wilson, Catherine Jardine, Mark Forrest, Emma Collins, Miqdad Ibrahim, Mark Wheeley, Mostafa Kodous, Mathew Blake, Victoria Lacey, Michael Eager, Robin Jootun, Janine Birch +657 morewiley +1 more sourceClinical Application of a Neonatal Delirium Screening Tool: A Feasibility Study
Acta Paediatrica, EarlyView.ABSTRACT Aims
The aims were as follows: (1) to adapt the Sophia Observation withdrawal Symptoms—Paediatric Delirium (SOS‐PD) screening tool for use in neonates (SOS‐ND), (2) to estimate the accuracy of SOS‐ND (used by nurses) compared to assessment by a child psychiatrist using an adapted version of Vanderbilt Assessment of Delirium in Infants and ...Rikke Louise Stenkjaer, Ingrid Egerod, Mala Moszkowicz, Erwin Ista, Gorm Greisen, Lise Aunsholt, Porntiva Poorisrisak, Suzanne Forsyth Herling +7 morewiley +1 more sourceClinical Course and Predictors of Biologic Therapy, Hospitalisation and Surgery: A Five‐Year Prospective Study in Newly Diagnosed Inflammatory Bowel Disease
Alimentary Pharmacology &Therapeutics, EarlyView.In this large multicentre Spanish inception cohort, biologics/JAK inhibitors were frequently used during the first 5 years after inflammatory bowel disease diagnosis and were associated with reduced hospitalisation risk, although not with lower abdominal surgery rates.Ana Garre, Andrea Nuñez Ortiz, Saioa Rubio, María Teresa Diz‐Lois Palomares, Sabino Riestra, Horacio Alonso‐Galán, Estela Fernández‐Salgado, Rocío Ferreiro‐Iglesias, Milagros Vela, Ángel Ponferrada Díaz, Eugenia Sánchez Rodríguez, Vicent Hernández, Lara Arias García, Jesús Barrio, José María Huguet, Daniel Ginard, Montserrat Rivero, Isabel Vera, Inmaculada Alonso‐Abreu, José Manuel Benítez, Mariam Aguas, Iago Rodríguez‐Lago, Xavier Calvet, Luis Fernández‐Salazar, Ana Echarri, María Teresa Arroyo, Mercè Navarro‐Llavat, Pablo Vega, Mónica Sierra, Elena Guerra del Río, Raquel Vicente, María José Casanova, Pablo Navarro, Jone Ortiz de Zarate, Pilar Varela Trastoy, Katerina Spicakova, Ana Gutiérrez, María Dolores Martín‐Arranz, Concepción Piñero, Álvaro Hernández‐Martínez, Emilio Torrella Cortés, José Miguel Marrero, Rufo H. Lorente Poyatos, Lidia Martí Romero, Orencio Bosch, José María Duque, Montserrat Aceituno, Hipólito Fernández, Belén Crespo Suarez, Ana María Fuentes Coronel, Liliana Pozzati, Pilar Robledo, Eva Sesé Abizanda, Belén Herreros Martínez, Nuria Jiménez, Pilar López Serrano, Manuela Josefa Sampedro, Fernando Bermejo, Alfredo J. Lucendo, Margarita Muñoz Vicente, Margarita Menacho, José Joaquín Ramírez Palanca, Raquel Camargo, Amalia Carmona, Sandra Torra Alsina, Margalida Calafat, José Luis F. Forcelledo, Juan Nerín de la Puerta, Isabel Nicolás, Verónica Opio, Yolanda Ber, Abdel Bouhmidi, Alfredo Abraldes Bechiarelli, Carlos Castaño‐Milla, Noelia Cruz, Jordi Gordillo, Amparo Sapiña, Alina López, Silvia Rodríguez Mondéjar, María Teresa Novella Durán, Belén Botella, Marcos Kutz, Lilyan Kolle, Ignacio Marín‐Jiménez, Francisco J. Martínez‐Cerezo, Rebeca Irisarri, Eduardo Iyo, Óscar Roncero, Miriam Sabat, Yolanda Torres Domínguez, Cesar Ledezma, Eva María Zapata, María José Alcalá, Laia Lluis, Cristina Martínez Pascual, Isabel Blázquez Gómez, Luis Hernández, Laura Mata, Ana Monrobel, Alejandro Hernández Camba, Nuria Maroto, María Tejada, María Luisa Galve, María Montealegre, Daniel Hervías, Marta Soler, José Antonio Gómez‐Valero, Manuel Barreiro‐de Acosta, Pilar Soto Escribano, José Luis Cabriada, Daniel Ceballos, Maria Esteve, Alba García Rodríguez, Vanesa Royo, Fernando Gomollón, Cristina Verdejo Gil, Pilar Nos, Ruth de Francisco, María José García, Carmen Dueñas Sadornil, Cristina Rodríguez, Beatriz Sicilia, Borja M. Fernandez‐Felix, Javier P. Gisbert, María Chaparro, on behalf of the EpidemIBD Group of GETECCU, Alfredo Abraldes Bechiarelli, José Manuel Benítez, María del Rosario Calderón, Raquel Camargo, Álvaro Hernández‐Martínez, Eva Iglesias Flores, Eduardo Leo Carnerero, Sandra Marín Pedrosa, Ana Monrobel, Andrea Núñez Ortiz, Natalia Ruiz Santana, María Tejada, Yolanda Torres Domínguez, María José Alcalá, Erika Alfambra, Yolanda Ber, Fernando Gomollón, Miguel Montoro, Juan Manuel Nerín, Elena Peña, Raquel Vicente, José María Duque, Ruth de Francisco, Alejo Mancebo Mata, Susana Martínez González, Isabel Pérez Martínez, Sabino Riestra, Pilar Varela Trastoy, Inmaculada Alonso‐Abreu, Daniel Ceballos, Noelia Cruz, Elena Guerra del Río, Alejandro Hernández Camba, Lilian Kole, José Miguel Marrero, Nuria Pérez, Marta Soler, Milagros Vela, José Luis F Forcelledo, Montserrat Rivero, Rufo Lorente Poyatos, Cristina Verdejo Gil, María Montealegre, Alfredo J Lucendo, Óscar Roncero, Abdel Bouhmidi, Daniel Hervías, Lara Arias García, Jesús Barrio, Ana Y Carbajo, Luis Fernández‐Salazar, Paola Fradejas, Ana María Fuentes Coronel, Luis Hernández, Carmen López Ramos, Laura Mata, Concepción Piñero, Beatriz Sicilia, Mónica Sierra, Mónica Vásquez, Montserrat Aceituno, Michelle Bautista, Xavier Calvet, Maria Esteve Comas, Antonia Montserrat, José Antonio Gómez Valero, Jordi Gordillo, Cesar Ledezma, Laia Lluis, Francisco J. Martínez‐Cerezo, Margarita Menacho, Mercè Navarro‐Llavat, Silvia Rodríguez Mondéjar, Miriam Sabat, Manuela Josefa Sampedro, Eva Sesé Abizanda, Anibal Silva, Sandra Torra Alsina, Leyanira Torrealba, Carmen Vila Lolo, Marta Ágreda Chinea, Alicia Algaba, Fernando Bermejo, Isabel Blázquez Gómez, Orencio Bosch, Belén Botella, María José Casanova, Carlos Castaño‐Milla, María Chaparro, Rocío De Lucas, Mercedes Domínguez‐Antonaya, María G Donday, Almudena Durán, María Luisa Galve, Laura García Ramírez, Ana Garre, Javier P. Gisbert, Iván Guerra, Paloma Jiménez, Beatriz López Cauce, Antonio López‐Sanromán, Pilar López Serrano, Ignacio Marín‐Jiménez, María Dolores Martín‐Arranz, José Antonio Olmos Jerez, Verónica Opio, José Lázaro Pérez Calle, Rocío Plaza Santos, Ángel Ponferrada Díaz, Elena San Miguel, Eugenia Sánchez Rodríguez, Isabel Vera‐Mendoza, Mariam Aguas, Marífé García‐Sepulcre, Ana Gutiérrez, Belén Herreros Martínez, José María Huguet, Nuria Jiménez, Nuria Maroto, Lidia Martí Romero, Miguel Mínguez, Margarita Muñoz Vicente, Pablo Navarro, Pilar Nos, José Joaquín Ramírez Palanca, Marisa Roldán Lafuente, Liliana Pozzati, Pilar Robledo, Manuel Barreiro‐de Acosta, Iria Bastón –Rey, Amalia Carmona, Daniel Carpio, Elena Castro, Belén Crespo Suarez, María Teresa Diz‐Lois Palomares, Ana Echarri, Jesús Daniel Fernández‐de Castro, Estela Fernández Salgado, Rocío Ferreiro‐Iglesias, Vicent Hernández, Alina López Baz, Pablo Pérez Galindo, María Jesús Ruiz Barcia, Pablo Vega, Margalida Calafat, Daniel Ginard, Eduardo Iyo, María Teresa Novella Durán, Josep Reyes, Carolina Rodríguez Hidalgo, Vanesa Royo, Amparo Sapiña.r, Ana Belen Aliende, Hipólito Fernández Rosáenz, María Fraile González, Alba García Rodríguez, Berta Lapeña Muñoz, María Teresa Moyano, Susana Revuelta Martínez, Rebeca Irisarri, Marcos Kutz, Óscar Nantes, Cristina Rodríguez, Saioa Rubio, Miren Vicuña, Horacio Alonso, Jose Luis Cabriada, Agustin Castiella Eguzkiza, Itziar Galdona, Ainara Maíz, Ana Isabel Muñagorri Santos, Nerea Muro Carral, Jone Ortiz de Zarate, Nora Otegui, Iago Rodríguez‐Lago, Katerina Spicakova, Eva María Zapata, Leire Zubiaurre Lizarralde, Jose Manuel Castillo Espinosa, María del Carmen Martínez Bonil, Cristina Martínez Pascual, Isabel Nicolás, Emilio Torrella Cortés +308 morewiley +1 more source
