Results 51 to 60 of about 217,312 (308)

Systems of Care for Treating Severe Acquired Brain Injury: Comparing the United States to Italy

Brain Sciences
Acquired Brain Injury (ABI) is now widely regarded as a chronic condition but this change in conceptualization has not yet been realized in the way rehabilitation and care are offered and funded in the United States. Similarly, it is widely accepted that
Nicholas J Cioe, Rita Formisano, Gregory O’Shanick, Juliet Haarbauer-Krupa, Valentina Bandiera, Elisa Berardi, Vincenzo Vinicola, Umberto Bivona   +7 more
doaj   +1 more source

Fumarate Hydratase Lactylation Exacerbates Traumatic Brain Injury Pathology via Mitochondrial Dysfunction and Neuroinflammation

Advanced Science, EarlyView.
Tian et al. reveal that FH K112 lactylation is elevated after TBI, leading to fumarate accumulation, mitochondrial damage, mtDNA release and amplified neuroinflammation. AARS2 and SIRT3 act as the “writer” and “eraser” for FH K112 lactylation. The peptide Pep‐K112 targeting this site alleviates brain injury, highlighting a potential therapeutic target.
Yang Tian, Shuoyao Ma, Bo Yang, Fei Gao, Hao Guo, Haixiao Liu, Xun Wu, Wenxing Cui, Jingyu Dong, Qian Lin, Yufeng Ge, Jin Ma, Jiazhen Zhao, Yongzhi Zhang, Dongzhi Xue, Jiaxin Tian, Ziwen Zhang, Kai Wang, Meng Xu, Dayun Feng, Jinpeng Zhou, Yan Qu   +21 more
wiley   +1 more source

Precision Nanomedicine for Traumatic Neural Injury: Functional Paradigms and Translational Frameworks

Advanced Science, EarlyView.
This review presents a pathology‐driven framework unifying nanomedicine across TBI, SCI, and PNI. Epidemiological evidence and comparative single‐cell transcriptomic reanalysis define shared pathological modules, injury‐specific effectors, and therapeutic bottlenecks. Six functional paradigms connect nanomaterial structure and biological fate to injury‐
Mouyuan Sun, Shuangyang Li, Zhixu He, Jingyi Xie, Yaxian Luo, Xuankai Fan, Jingyu Zhang, Luying Qin, Lianjie Peng, Tao Qiu, Tian Zhang, Huiming Wang, Mengfei Yu   +12 more
wiley   +1 more source

An Environmental Stable Ionogel‐Based Smart Glove System for Integrated Underwater Communication and Safety Warning

Advanced Science, EarlyView.
This study develops a smart glove by integrating a P(BZMA‐co‐HEA)/IL ionogel with a reconfigurable FPCB for underwater communication and real‐time safety warning. The network‐constrained ionic soft‐space regulation strategy enables mechanical reliability, environmental stability, and sensing adaptability, while the modular FPCB sensor array simplifies ...
Xiaoqin Li, Jianwen Liu, Wenhao Yang, Wenjing Yue, Nam‐Young Kim, Young‐Kee Shin, Song Gao, Eun‐Seong Kim, Yang Li   +8 more
wiley   +1 more source

Lactylation of HSC70 Impairs Chaperone‐Mediated Autophagy to Promote Pyrin Inflammasome‐Dependent PANoptosis in Macrophages During Sepsis

Advanced Science, EarlyView.
In sepsis, lactate accumulation drives HSC70 K561 lactylation, which impairs chaperone‐mediated autophagy and blocks CUX1 degradation. Accumulated CUX1 transcriptionally upregulates Pyrin, triggering PANoptosis in macrophages and exacerbating inflammatory storm and organ injury.
Ying Chen, Yan Zhang, Pei Wang, Jiamin Ma, Xinru Zhao, Yi Li, Zhenghao Deng, Xueqing Meng, Jiali Zhu, Liangfang Yao, Jinbao Li   +10 more
wiley   +1 more source

Spasticity Management in Disorders of Consciousness

Brain Sciences, 2017
Background: Spasticity is a motor disorder frequently encountered after a lesion involving the central nervous system. It is hypothesized to arise from an anarchic reorganization of the pyramidal and parapyramidal fibers and leads to hypertonia and ...
Géraldine Martens, Steven Laureys, Aurore Thibaut   +2 more
doaj   +1 more source

Genetic Variants of Na+,K+‐ATPase Associated With Neurological Disorders: A Systematic Review

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Neurological disorders encompass a wide range of severe symptoms and manifestations, many of which are associated with genetic variants that affect ionic homeostasis. Na+,K+‐ATPase, a transmembrane enzyme responsible for maintaining electrochemical gradients in cells, plays a crucial role in neuronal excitability and brain function.
Giovana Kummer da Rosa, Leandro Rodrigo Ribeiro, Jéssica Lorena Bariviera, Mauro Schneider Oliveira   +3 more
wiley   +1 more source

Vigo. Llegada del pescado

, 1906
Reverso da postal sen dividirSen circularNo recto, na parte superior: "Postales Coma, Vigo"Resumen: Imaxe da vida cotiá no peirao coa chegada do ...
Coma, Vicente (editor)
core  

Morphological variation of the conus arteriosus in Chondrichthyes: Implications for ecology and evolution

The Anatomical Record, EarlyView.
Abstract Cartilaginous fish have diverse morphological traits that are essential for understanding their evolutionary history and ecological adaptations. However, the conus arteriosus and its valves, key components of the heart and blood circulation, have been underexplored in phylogenetic and ecomorphological contexts.
Maria Clara El Bayeh de Andrade, Karla Diamantina de Araújo Soares   +1 more
wiley   +1 more source

Creación y osadía

, 2007
Sección de teatro de la revista Mephisto por Marina Coma Díaz.Depto. de Estudios Ingleses: Lingüística y LiteraturaFac.
Coma Diaz, Marina
core   +1 more source