Results 141 to 150 of about 252,941 (311)
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
A Multi-Step Forecast Density [PDF]
This paper makes two contribution to the literature on density forecasts. First, we propose a novel bootstrap approach to estimate forecasting densities based on nonparametric techniques.
Manzan, S., Zerom, D.
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AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
A hierarchical procedure for the combination of forecasts [PDF]
, 2009 This paper proposes a strategy to increase the efficiency of forecast combination. Given the availability of a wide range of forecasts for the same variable of interest, our goal is to apply combining methods to a restricted set of models. To this aim, a
Costantini, Mauro, Pappalardo, Carmine
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pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Forecasts of U.S. short-term interest rates: a flexible forecast combination approach [PDF]
This paper develops a flexible approach to combine forecasts of future spot rates with forecasts from time-series models or macroeconomic variables.
Allan Timmerman, Massimo Guidolin
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FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
The shrinkage approach in the combination of forecasts [PDF]
, 2000 An unbiased point estimator T for an unknown parameter q can be improved in the sense of the Mean Squared Error (MSE) by T T l= l for suitable factors l. Here, we want to discuss this approach in the context of combination of forecasts.
Wenzel, Thomas
core +1 more source
The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
Hierarchical forecasts for Australian domestic tourism [PDF]
In this paper we explore the hierarchical nature of tourism demand time series and produce short-term forecasts for Australian domestic tourism.
George Athanasopoulos +2 more
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