Results 161 to 170 of about 252,941 (311)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Averaging forecasts from VARs with uncertain instabilities [PDF]

A body of recent work suggests commonly–used VAR models of output, inflation, and interest rates may be prone to instabilities. In the face of such instabilities, a variety of estimation or forecasting methods might be used to improve the accuracy of ...
Michael W. McCracken, Todd E. Clark
core  

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Ensemble forecasts of COVID-19 activity to support Australia's pandemic response: 2020-22. [PDF]

PLoS Comput Biol
Moss R, Tobin RJ, O'Hara-Wild M, Adekunle AI, Liu D, South T, Morris DJ, Ryan GE, Hao T, Babu A, Senior KL, Wood JG, Golding N, Ross JV, Dawson P, Hyndman RJ, Price DJ, McCaw JM, Shearer FM.   +18 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Weather forecasts become more important for reducing mortality as the climate warms. [PDF]

Proc Natl Acad Sci U S A
Shrader JG, Thies S, Bakkensen L, Linsenmeier M, Lemoine D.   +4 more
europepmc   +1 more source

Investor sentiment and return predictability in agricultural futures markets [PDF]

This study examines the usefulness of trader-position-based sentiment index for forecasting future prices in six major agricultural futures markets. It has been found that large speculator sentiment forecasts price continuations.
Wang, Changyun
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Precipitation forecasting utility for proactive agroecosystem management: A case study from the Texas Gulf LTAR site. [PDF]

J Environ Qual
Schantz MC, Hardegree SP, Abatzoglou JT, Fullhart A, Adhikari K, Harmel RD, Thorp KR, Leyton JO, Smith DR.   +8 more
europepmc   +1 more source

Using Seasonal Models to Forecast Short-Run Inflation in Mexico. [PDF]

Since the adoption of inflation targeting, the seasonal appears to be the component that explains the major part of inflation's total variation in Mexico.
Carlos Capistrán, Christian Constandse, Manuel Ramos Francia   +2 more
core