Results 81 to 90 of about 20,414 (267)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Why Do DJF 2023/24 Upper‐Level 200‐hPa Geopotential Height Forecasts Look Different From the Expected El Niño Response?

open access: yesGeophysical Research Letters
We investigate why the North American Multi‐Model Ensemble (NMME) upper‐level height forecast for December–February (DJF) 2023/24 differs from the expected El Niño response.
Mingyue Chen   +6 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Convergence Index: a new performance measure for the temporal stability of operational rainfall forecasts

open access: yesMeteorologische Zeitschrift, 2010
In this study, a new performance measure is presented which evaluates to what extent a sequence of forecasts converges, with decreasing lead time, towards the observation without oscillation. Convergence and non-oscillation are important quality criteria
Uwe Ehret
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Sentiment Analysis as an Innovation in Inflation Forecasting in Romania [PDF]

open access: yesMarketing i Menedžment Innovacij
Romania faced the highest inflation rate in the European Union at the beginning of 2024, but progress has been made compared to that in 2023 due to the increasing interest rate.
doaj   +1 more source

COMBINING COMBINED FORECASTS: A NETWORK APPROACH

open access: yes
This paper studies how communication across experts prior to aggregation by a decision-maker affects the efficiency of forecast combination. When experts exchange information before reporting their forecasts, their signals become correlated through the communication network, altering aggregation efficiency even when forecasts are unbiased. The analysis
openaire   +2 more sources

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

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