Results 1 to 10 of about 2,643,192 (369)

Optimized Treatment Schedules for Chronic Myeloid Leukemia [PDF]

, 2016
Over the past decade, several targeted therapies (e.g. imatinib, dasatinib, nilotinib) have been developed to treat Chronic Myeloid Leukemia (CML). Despite an initial response to therapy, drug resistance remains a problem for some CML patients. Recent studies have shown that resistance mutations that preexist treatment can be detected in a substan ...
Dingli, David, Foo, Jasmine, He, Qie, Leder, Kevin, Zhu, Junfeng   +4 more
arxiv   +5 more sources

Systems approaches and algorithms for discovery of combinatorial therapies [PDF]

WIREs Syst Biol Med 2009, 2009
Effective therapy of complex diseases requires control of highly non-linear complex networks that remain incompletely characterized. In particular, drug intervention can be seen as control of signaling in cellular networks. Identification of control parameters presents an extreme challenge due to the combinatorial explosion of control possibilities in ...
Agoston V, Balamurugan D, Calzolari D, Carlson JM, Greco WR, Johannesson GH, Nelander S, Segota E, Spall JC, Wadman M, Weinberg RA, Yang K   +11 more
arxiv   +3 more sources

Radionuclide-labelled nanoparticles for cancer combination therapy: a review [PDF]

Journal of Nanobiotechnology
Radionuclide therapy (RT) is widely used to advanced local cancers. However, its therapeutic efficacy is limited to the radiation resistance of cancer cells.
Na Sun, Tao Wang, Song Zhang
doaj   +2 more sources

Combination Therapies with PRRT [PDF]

Pharmaceuticals, 2021
Peptide receptor radionuclide therapy (PRRT) is a successful targeted radionuclide therapy in neuroendocrine tumors (NETs). However, complete responses remain elusive. Combined treatments anticipate synergistic effects and thus better responses by combining ionizing radiation with other anti-tumor treatments.
Anna Yordanova, Hojjat Ahmadzadehfar
openaire   +3 more sources

Synergetic Thermal Therapy for Cancer: State-of-the-Art and the Future

Bioengineering, 2022
As a safe and minimal-invasive modality, thermal therapy has become an effective treatment in cancer treatment. Other than killing the tumor cells or destroying the tumor entirely, the thermal modality results in profound molecular, cellular and ...
Qizheng Dai, Bo Cao, Shiqing Zhao, Aili Zhang   +3 more
doaj   +1 more source

Practical efficacy and safety of Konsilar D24 in patients with hypertension: data from the KONSONANS program

Российский кардиологический журнал, 2021
Aim. In practice, to evaluate the efficacy, safety and long-term adherence to therapy with a fixed-dose combination of ramipril/indapamide (Konsilar-D24) in patients with grade 1-2 hypertension (HTN) who have not achieved blood pressure (BP) control with
A. O. Konradi, A. S. Galyavich, V. V. Kashtalap, Yu. M. Lopatin, N. P. Lyamina, S. V. Nedogoda, A. O. Nedoshivin, G. I. Nechaeva, L. G. Ratova, I. I. Shaposhnik   +9 more
doaj   +1 more source

Targeted c-Myc Inhibition and Systemic Temozolomide Therapy Extend Survival in Glioblastoma Xenografts

Bioengineering, 2023
Glioblastoma is a highly aggressive disease with poor patient outcomes despite current treatment options, which consist of surgery, radiation, and chemotherapy.
Laxmi Dhungel, Cayla Harris, Lauren Romine, Jan Sarkaria, Drazen Raucher   +4 more
doaj   +1 more source

Perfecting the Puzzle of Pathophysiology: Exploring Combination Therapy in the Treatment of Type 2 Diabetes

Diabetology, 2023
Type 2 diabetes mellitus (T2DM) is a debilitating, lifelong condition with a rising incidence. A wide variety of antihyperglycemic agents are available on the market to treat diabetes. However, the number of patients living with diabetes under suboptimal
Ridhi Gudoor, Austen Suits, Jay H. Shubrook   +2 more
doaj   +1 more source

Combination anti-coronavirus therapies based on nonlinear mathematical models [PDF]

CHAOS, 31, 023136 (2021), 2021
Using nonlinear mathematical models and experimental data from laboratory and clinical studies, we have designed new combination therapies against COVID-19.
arxiv   +1 more source

Combination therapy for cough and bronchial obstruction in childhood

Медицинский совет, 2019
The inflammatory process in the bronchial mucosa of various origins (infectious, allergic, irritative, etc.) cause changes in the sputum production and its rheological properties, slowing of mucociliary clearance.
Yu. L. Mizernitskiy, N. L. Dorovskaya, I. M. Melnikova   +2 more
doaj   +1 more source