Results 31 to 40 of about 10,851,050 (358)

Perfecting the Puzzle of Pathophysiology: Exploring Combination Therapy in the Treatment of Type 2 Diabetes

open access: yesDiabetology, 2023
Type 2 diabetes mellitus (T2DM) is a debilitating, lifelong condition with a rising incidence. A wide variety of antihyperglycemic agents are available on the market to treat diabetes. However, the number of patients living with diabetes under suboptimal
Ridhi Gudoor   +2 more
doaj   +1 more source

Olmesartan-based monotherapy vs combination therapy in hypertension: A meta-analysis based on age and chronic kidney disease status. [PDF]

open access: yes, 2017
Antihypertensive monotherapy is often insufficient to control blood pressure (BP). Several recent guidelines advocate for initial combination drug therapy in many patients. This meta-analysis of seven randomized, double-blind studies (N = 5888) evaluated
Bakris, George   +3 more
core   +1 more source

Radiation Therapy in Keloids Treatment: History, Strategy, Effectiveness, and Complication

open access: yesChinese Medical Journal, 2017
Objective: Radiation therapy combined with surgical excision was considered as one of the most effective treatment plans for keloid lesions. However, there was no unanimity found over present literatures regarding the issue on optimized treatment ...
Jing Xu, Elan Yang, Nan-Ze Yu, Xiao Long
doaj   +1 more source

Combination therapy in combating cancer

open access: yesOncoTarget, 2017
Combination therapy, a treatment modality that combines two or more therapeutic agents, is a cornerstone of cancer therapy. The amalgamation of anti-cancer drugs enhances efficacy compared to the mono-therapy approach because it targets key pathways in a
R. Mokhtari   +6 more
semanticscholar   +1 more source

Challenges of combination therapy with immune checkpoint inhibitors for hepatocellular carcinoma.

open access: yesJournal of Hepatology, 2020
Immune checkpoint inhibitor (ICI) therapy targeting anti-programmed cell death-1 (anti-PD-1) or its ligand (anti-PD-L1) is the backbone of numerous combination regimens aimed at improving the objective response and survival of patients with ...
A. Cheng   +4 more
semanticscholar   +1 more source

Design and Characterization of a Novel Venetoclax-Zanubrutinib Nano-Combination for Enhancing Leukemic Cell Uptake and Long-Acting Plasma Exposure

open access: yesPharmaceutics, 2023
Leukemia remains incurable partly due to difficulties in reaching and maintaining therapeutic drug concentrations in the target tissues and cells. Next-generation drugs targeted to multiple cell checkpoints, including the orally active venetoclax (Bcl-2 ...
James Griffin   +4 more
doaj   +1 more source

MTOR cross-talk in cancer and potential for combination therapy [PDF]

open access: yes, 2018
The mammalian Target of Rapamycin (mTOR) pathway plays an essential role in sensing and integrating a variety of exogenous cues to regulate cellular growth and metabolism, in both physiological and pathological conditions.
Bazzichetto, C.   +7 more
core   +3 more sources

Efficacy of Elaborated Semantic Features Analysis in Aphasia: a quasi-randomised controlled trial [PDF]

open access: yes, 2019
Background: Word finding difficulty is one of the most common features of aphasia. Semantic Features Analysis (SFA) directly aims to improve word finding in people with aphasia.
Elman R.   +13 more
core   +1 more source

Combination therapy of hypertension

open access: yesМедицинский совет, 2015
The article is a short overview of articles related to the prescription of combination antihypertensive therapy. The focus is on the evidence of administration of a fixed combination - lercanidipine plus enalapril, which is characterized by a high ...
O. O. Bolshakova
doaj   +1 more source

Combination therapy for hypertension

open access: yesSouth African Family Practice, 2005
No abstract available.
J.A. Ker
doaj   +1 more source

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