Results 51 to 60 of about 10,851,050 (358)

Efficacy and safety of anticancer drug combinations: a meta-analysis of randomized trials with a focus on immunotherapeutics and gene-targeted compounds. [PDF]

, 2020
Hundreds of trials are being conducted to evaluate combination of newer targeted drugs as well as immunotherapy. Our aim was to compare efficacy and safety of combination versus single non-cytotoxic anticancer agents. We searched PubMed (01/01/2001 to 03/
Barkauskas, Donald A, De Melo Gagliato, Débora, Jardim, Denis L, Kurzrock, Razelle, Nikanjam, Mina   +4 more
core   +1 more source

Combination Cancer Therapy and Reference Models for Assessing Drug Synergy in Glioblastoma

Current Oncology
Glioblastoma is currently an incurable disease despite the development of a wide variety of therapeutic approaches, from surgical methods to immunotherapy.
Semyon A. Sinyavskiy, Nelly S. Chmelyuk, Daria Yu. Travnikova, Vsevolod V. Belousov, Tatiana O. Abakumova   +4 more
doaj   +1 more source

PHOTODYNAMIC THERAPY FOR LUNG CANCER: MAJOR INDICATIONS

Сибирский онкологический журнал, 2016
Lung cancer treatment remains a major challenge for modern oncology. Photodynamic therapy (PDT) has proved to be an effective anti-tumor treatment modality for patients with lung cancer. This paper evaluated results of using PDT for lung cancer patients.
Yu. A. Ragulin, V. N. Galkin
doaj   +1 more source

A Systematic Review of therapeutic agents for the treatment of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) [PDF]

, 2019
Background The Middle East Respiratory Syndrome Coronavirus (MERS-CoV) was first described in 2012 and attracted a great international attention due to multiple healthcare associated outbreaks.
Al-Ali, Anfal Y., Al-Tawfiq, Jaffar A., Momattin, Hisham   +2 more
core   +1 more source

Omadacycline Potentiates Clarithromycin Activity Against Mycobacterium abscessus

Frontiers in Pharmacology, 2021
Mycobacterium abscessus is a difficult respiratory pathogen to treat, when compared to other nontuberculus mycobacteria (NTM), due to its drug resistance.
Bui Thi Bich Hanh, Nguyen Thanh Quang, Yujin Park, Bo Eun Heo, Seunghyeon Jeon, June-Woo Park, Jichan Jang, Jichan Jang   +7 more
doaj   +1 more source

Synthetic Lethality of Chk1 Inhibition Combined with p53 and/or p21 Loss During a DNA Damage Response in Normal and Tumor Cells [PDF]

, 2013
Cell cycle checkpoints ensure genome integrity and are frequently compromised in human cancers. A therapeutic strategy being explored takes advantage of checkpoint defects in p53-deficient tumors in order to sensitize them to DNA-damaging agents by ...
A Besson, A Eastman, A Goga, A Goloudina, A Z Munir, AA Levesque, AA Levesque, AJ Fikaris, AN Tse, AT Ferguson, B Xu, C Tapia, CJ Sherr, CS Sorensen, CX Ma, EA Kohn, EA Kohn, F Bunz, FI Raynaud, H Piwnica-Worms, H Zhao, I Hassepass, J Bartkova, J Falck, K Shimuta, L S White, LL Parker, MH Lam, MV Cespedes, O Gilad, O Wang, OA Sedelnikova, PM Fracasso, R Di Micco, R Rodriguez, RP Perez, RT Bunch, S Origanti, S-r Cai, SD Zabludoff, T Abbas, T Waldman, WR Taylor, Y Luo   +43 more
core   +2 more sources

Why and When Are Evidence‐Based Interventions Adopted in Paediatric Supportive Care? A Qualitative Exploration of the Determinants of Photobiomodulation Implementation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Oral mucositis is a common and debilitating side effect of childhood cancer and stem cell transplant treatments. It affects the quality of life of children and young people (CYP) and places a strain on services. Photobiomodulation is recommended for oral mucositis prevention in international guidance but is poorly implemented in UK ...
Claudia Heggie, Kara A. Gray‐Burrows, Peter F. Day, Bob Phillips, Carl A. Thompson   +4 more
wiley   +1 more source

Combination Therapy Is Not Associated with Decreased Mortality in Infectious Endocarditis: A Systematic Review and Meta-Analysis

Microorganisms
Untreated infective endocarditis (IE) is uniformly fatal. The practice of combination antibiotic therapy for IE is recommended by treatment guidelines but largely unsupported by high-quality evidence.
Parisa Farahani, Felicia Ruffin, Mohammad Taherahmadi, Maren Webster, Rachel E. Korn, Sarah Cantrell, Lana Wahid, Vance G. Fowler, Joshua T. Thaden   +8 more
doaj   +1 more source

Molecular profiling of cancer patients enables personalized combination therapy: the I-PREDICT study

Nature Medicine, 2019
Cancer treatments have evolved from indiscriminate cytotoxic agents to selective genome- and immune-targeted drugs that have transformed the outcomes of some malignancies1. Tumor complexity and heterogeneity suggest that the ‘precision medicine’ paradigm
J. Sicklick, S. Kato, R. Okamura, Maria C. Schwaederlé, Michael E. Hahn, C. Williams, P. De, A. Krie, D. Piccioni, V. Miller, J. S. Ross, J. S. Ross, A. Benson, J. Webster, P. Stephens, J. Lee, P. Fanta, S. Lippman, B. Leyland-Jones, R. Kurzrock   +19 more
semanticscholar   +1 more source

Local Lung Targeting of Tumor Associated Macrophages Combined with Cytoreductive Therapy Decrease Tumor Burden in a Secondary Lung Cancer Model [PDF]

, 2020
Backgrounds. The efficacy of a locally administered small molecule colony stimulating factor 1 receptor inhibitor (CSF-1Ri), PLX3397, alone or in combination with cytoreductive therapy (paclitaxel) in reducing the tumor burden of an in vivo model of ...
Alhudaithi, Sulaiman, Almuqbil, Rashed, Bos, Paula, da Rocha, Sandro, Du, Wei, Sunbul, Fatemah, Zhang, Hanming   +6 more
core   +1 more source