Two-year follow-up of macaques developing intermittent control of the human immunodeficiency virus homolog simian immunodeficiency virus SIVmac251 in the chronic phase of infection [PDF]
, 2015 Off-therapy control of viremia by HIV-infected individuals has been associated with two likely players: a restricted viral reservoir and an efficient cell-mediated immune response.
Arts, Eric +14 more
core +2 more sources
MTOR cross-talk in cancer and potential for combination therapy [PDF]
, 2018 The mammalian Target of Rapamycin (mTOR) pathway plays an essential role in sensing and integrating a variety of exogenous cues to regulate cellular growth and metabolism, in both physiological and pathological conditions.
Bazzichetto, C. +7 more
core +3 more sources
A synthetic-lethality RNAi screen reveals an ERK-mTOR co-targeting pro-apoptotic switch in PIK3CA+ oral cancers. [PDF]
, 2016 mTOR inhibition has emerged as a promising strategy for head and neck squamous cell carcinomas (HNSCC) treatment. However, most targeted therapies ultimately develop resistance due to the activation of adaptive survival signaling mechanisms limiting the ...
Amornphimoltham, Panomwat +10 more
core +1 more source
Combination therapy of hypertension
Медицинский совет, 2015 The article is a short overview of articles related to the prescription of combination antihypertensive therapy. The focus is on the evidence of administration of a fixed combination - lercanidipine plus enalapril, which is characterized by a high ...
O. O. Bolshakova
doaj +1 more source
Combination inhaled steroid and long-acting beta-agonist in addition to tiotropium versus tiotropium or combination alone for chronic obstructive pulmonary disease (Review) [PDF]
, 2011 Background The long-acting bronchodilator tiotropium and single inhaler combination therapy of inhaled corticosteroids and long-acting beta(2)-agonists are both commonly used for maintenance treatment of chronic obstructive pulmonary disease.
Appleton +10 more
core +1 more source
Combination therapy for hypertension
South African Family Practice, 2005 No abstract available.
J.A. Ker
doaj +1 more source
Life expectancy of persons receiving combination antiretroviral therapy in low-income countries: a cohort analysis from Uganda [PDF]
, 2011 Little is known about the effect of combination antiretroviral therapy (cART) on life expectancy in sub-Saharan ...
Bakanda, Celestin +8 more
core +2 more sources
Combination therapy in hypertension
South African Family Practice, 2007 Hypertension is one of the most important risk factors for death, heart failure, ischaemic heart disease, stroke and chronic kidney disease. Treatment of hypertension to particularly to goal blood pressure (BP) prevents these complications.
Brian Rayner
doaj +1 more source
Efficacy of Elaborated Semantic Features Analysis in Aphasia: a quasi-randomised controlled trial [PDF]
, 2019 Background: Word finding difficulty is one of the most common features of aphasia. Semantic Features Analysis (SFA) directly aims to improve word finding in people with aphasia.
Elman R. +13 more
core +1 more source
Combinatorial functions of two chimeric antibodies directed to human CD4 and one directed to the a-chain of the human interleukin-2 receptor [PDF]
, 1992 The general feasibility of chimerization of monoclonal antibodies (mAbs) has already been shown for a large number of them. In order to evaluate in vitro parameters relevant to immunosuppressive therapy, we have chimerized and synthesized two anti-CD4 ...
Flieger, Dimitri +10 more
core +1 more source