Results 31 to 40 of about 2,646,844 (209)

A newly designed flexible hydrated-hardening bone graft (FHBG) promotes bone regeneration and in vivo calvarial repair

Biomedical Journal
Background: Autologous bone remains the gold standard for surgical bone reconstruction but presents clinical challenges like donor site complications and operational difficulties. Method: We investigate the osteogenic effects of a newly designed, ceramic
Wei-Ting Wang, Chun-Chieh Tseng, Huan-Chieh Cho, Kuan-Yu Chiu, Li-Wen Weng, Yen-Hao Chang, Rong-Fu Chen, Su-Shin Lee, Yi-Chia Wu   +8 more
doaj   +1 more source

Customizing the therapeutic response of signaling networks to promote antitumor responses by drug combinations [PDF]

, 2014
Drug resistance, de novo and acquired, pervades cellular signaling networks (SNs) from one signaling motif to another as a result of cancer progression and/or drug intervention.
Bown, James L., Goltsov, Alexey, Goltsov, Gregory, Harrison, David J., Langdon, Simon P.   +4 more
core   +5 more sources

PHOTODYNAMIC THERAPY FOR LUNG CANCER: MAJOR INDICATIONS

Сибирский онкологический журнал, 2016
Lung cancer treatment remains a major challenge for modern oncology. Photodynamic therapy (PDT) has proved to be an effective anti-tumor treatment modality for patients with lung cancer. This paper evaluated results of using PDT for lung cancer patients.
Yu. A. Ragulin, V. N. Galkin
doaj   +1 more source

One year follow-up of a randomized trial with a dilemma-focused intervention for depression: Exploring an alternative to problem-oriented strategies [PDF]

, 2018
© 2018 Feixas et al.Cognitive behavioural therapy (CBT) is aimed to counteract cognitions and behaviours that are considered as dysfunctional. The aim of the study is to test whether the inclusion of a non-counteractive approach (dilemma-focused ...
Aguilera, M., Bados, A., Codina, J., Compan, V., Feixas, Guillem, Garcia-Grau, E., Guasch, V., Medina, Joan Carlos, Montesano, A., Ortiz, E., Paz, Clara, Sala, M., Trujillo, A., Winter, David   +13 more
core   +5 more sources

Combination Cancer Therapy and Reference Models for Assessing Drug Synergy in Glioblastoma

Current Oncology
Glioblastoma is currently an incurable disease despite the development of a wide variety of therapeutic approaches, from surgical methods to immunotherapy.
Semyon A. Sinyavskiy, Nelly S. Chmelyuk, Daria Yu. Travnikova, Vsevolod V. Belousov, Tatiana O. Abakumova   +4 more
doaj   +1 more source

Omadacycline Potentiates Clarithromycin Activity Against Mycobacterium abscessus

Frontiers in Pharmacology, 2021
Mycobacterium abscessus is a difficult respiratory pathogen to treat, when compared to other nontuberculus mycobacteria (NTM), due to its drug resistance.
Bui Thi Bich Hanh, Nguyen Thanh Quang, Yujin Park, Bo Eun Heo, Seunghyeon Jeon, June-Woo Park, Jichan Jang, Jichan Jang   +7 more
doaj   +1 more source

Identification and Characterization of AES-135, a Hydroxamic Acid-Based HDAC Inhibitor That Prolongs Survival in an Orthotopic Mouse Model of Pancreatic Cancer [PDF]

, 2019
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive, incurable cancer with a 20% 1 year survival rate. While standard-of-care therapy can prolong life in a small fraction of cases, PDAC is inherently resistant to current treatments, and novel ...
Adile, Ashley A., Bakhshinyan, David, Berger-Becvar, Angelika, de Araujo, Elvin D., Deininger, Michael W., Fishel, Melissa L., Gawel, Justyna M., Geletu, Mulu, Grimard, Michelle L., Gunning, Patrick T., Heaton, William L., Konieczny, Stephen F., Luchman, H. Artee, O'Hare, Thomas, Raouf, Yasir, Shah, Fenil, Shouksmith, Andrew E., Singh, Sheila K., Venugopal, Chitra, Weiss, Samuel   +19 more
core   +3 more sources

Targeting tumour re-wiring by triple blockade of mTORC1, epidermal growth factor, and oestrogen receptor signalling pathways in endocrine-resistant breast cancer [PDF]

, 2018
Background Endocrine therapies are the mainstay of treatment for oestrogen receptor (ER)-positive (ER+) breast cancer (BC). However, resistance remains problematic largely due to enhanced cross-talk between ER and growth factor pathways, circumventing ...
A Carracedo, A Subramanian, AH Evans, Allan Thornhill, Alshad S. Lalani, Aradhana Rani, C Trapnell, CK Osborne, CX Ma, Eugene Schuster, FL Chen, Francesca Avogadri-Connors, G Arpino, HJ Burstein, IE Smith, J Baselga, Joanna Nikitorowicz-Buniak, KE Bachman, KE O'Reilly, L Gandhi, LA Martin, LA Martin, Lesley-Ann Martin, LV Sequist, M Arnedos, M Dowsett, Mitch Dowsett, MT Weigel, N Patani, N Simigdala, NA O'Brien, Nikiana Simigdala, R Ribas, Ricardo Ribas, Richard E. Cutler, S Johnston, SC Drury, SN Mohd Nafi, SP Newman, Stephanie K. Guest, Stephen R. Johnston, Sunil Pancholi, T Nagashima, W Luo   +43 more
core   +6 more sources

Combination Therapy Is Not Associated with Decreased Mortality in Infectious Endocarditis: A Systematic Review and Meta-Analysis

Microorganisms
Untreated infective endocarditis (IE) is uniformly fatal. The practice of combination antibiotic therapy for IE is recommended by treatment guidelines but largely unsupported by high-quality evidence.
Parisa Farahani, Felicia Ruffin, Mohammad Taherahmadi, Maren Webster, Rachel E. Korn, Sarah Cantrell, Lana Wahid, Vance G. Fowler, Joshua T. Thaden   +8 more
doaj   +1 more source

Nanoparticle-Assisted Sonosensitizers and Their Biomedical Applications

International Journal of Nanomedicine, 2021
Pengxuan Zhao,1 Youbin Deng,1 Guangya Xiang,2 Yani Liu1 1Department of Medical Ultrasound, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People’s Republic of China; 2School of Pharmacy, Tongji ...
Zhao P, Deng Y, Xiang G, Liu Y
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