Node-positive breast cancer: Which are the best chemotherapy regimens? [PDF]
, 2008 Breast cancer-associated mortality has been significantly reduced since the 1990s, mainly because of early diagnosis and systemic therapeutic interventions.
Bauerfeind, Ingo +5 more
core +2 more sources
PHOTODYNAMIC THERAPY FOR LUNG CANCER: MAJOR INDICATIONS
Сибирский онкологический журнал, 2016 Lung cancer treatment remains a major challenge for modern oncology. Photodynamic therapy (PDT) has proved to be an effective anti-tumor treatment modality for patients with lung cancer. This paper evaluated results of using PDT for lung cancer patients.
Yu. A. Ragulin, V. N. Galkin
doaj +1 more source
Optimal personalized therapies in colon-cancer induced immune response using a Fokker-Planck framework [PDF]
arXiv, 2022 In this paper, a new stochastic framework to determine optimal combination therapies in colon cancer-induced immune response is presented. The dynamics of colon cancer is described through an It\"o stochastic process, whose probability density function evolution is governed by the Fokker-Planck equation.
arxiv
Olmesartan-based monotherapy vs combination therapy in hypertension: A meta-analysis based on age and chronic kidney disease status. [PDF]
, 2017 Antihypertensive monotherapy is often insufficient to control blood pressure (BP). Several recent guidelines advocate for initial combination drug therapy in many patients. This meta-analysis of seven randomized, double-blind studies (N = 5888) evaluated
Bakris, George +3 more
core +1 more source
Computational model for tumor response to adoptive cell transfer therapy [PDF]
arXiv, 2022 One of the barriers to the development of effective adoptive cell transfer therapies (ACT), specifically for genetically engineered T-cell receptors (TCRs), and chimeric antigen receptor (CAR) T-cells, is target antigen heterogeneity. It is thought that intratumor heterogeneity is one of the leading determinants of therapeutic resistance and treatment ...
arxiv
MTOR cross-talk in cancer and potential for combination therapy [PDF]
, 2018 The mammalian Target of Rapamycin (mTOR) pathway plays an essential role in sensing and integrating a variety of exogenous cues to regulate cellular growth and metabolism, in both physiological and pathological conditions.
Bazzichetto, C. +7 more
core +3 more sources
Autophagy Modulation and Cancer Combination Therapy: A Smart Approach in Cancer Therapy
Cancer Treatment and Research Communications, 2022 The autophagy pathway is the process whereby cells keep cellular homeostasis and respond to stress via recycling their damaged cellular proteins, organelles, and other cellular components. In the context of cancer, autophagy is a dual-edge sword pro- and
Ali Salimi-Jeda +8 more
doaj
Nanoparticle-Based Combination Therapy for Melanoma
Frontiers in Oncology, 2022 Melanoma is a cutaneous carcinoma, and its incidence is rapidly increasing with every year. The treatment options for melanoma have been comprehensively studied.
Hongbo Chen +4 more
doaj +1 more source
Mathematical Model of the Impact of Chemotherapy and Anti-Angiogenic Therapy on Drug Resistance in Glioma Growth [PDF]
arXiv, 2023 This research presents a mathematical model of glioma growth dynamics with drug resistance, capturing interactions among five cell populations: glial cells, sensitive glioma cells, resistant glioma cells, endothelial cells, and neuron cells, along with two therapy agent populations: chemotherapy and anti-angiogenic therapy.
arxiv
Two-year follow-up of macaques developing intermittent control of the human immunodeficiency virus homolog simian immunodeficiency virus SIVmac251 in the chronic phase of infection [PDF]
, 2015 Off-therapy control of viremia by HIV-infected individuals has been associated with two likely players: a restricted viral reservoir and an efficient cell-mediated immune response.
Arts, Eric +14 more
core +2 more sources