A synthetic-lethality RNAi screen reveals an ERK-mTOR co-targeting pro-apoptotic switch in PIK3CA+ oral cancers. [PDF]
, 2016 mTOR inhibition has emerged as a promising strategy for head and neck squamous cell carcinomas (HNSCC) treatment. However, most targeted therapies ultimately develop resistance due to the activation of adaptive survival signaling mechanisms limiting the ...
Amornphimoltham, Panomwat +10 more
core +1 more source
Life expectancy of persons receiving combination antiretroviral therapy in low-income countries: a cohort analysis from Uganda [PDF]
, 2011 Little is known about the effect of combination antiretroviral therapy (cART) on life expectancy in sub-Saharan ...
Bakanda, Celestin +8 more
core +2 more sources
MicroorganismsUntreated infective endocarditis (IE) is uniformly fatal. The practice of combination antibiotic therapy for IE is recommended by treatment guidelines but largely unsupported by high-quality evidence.
Parisa Farahani +8 more
doaj +1 more source
Deterministic and Stochastic in-host Tuberculosis Models for Bacterium-directed and Host-directed Therapy Combination [PDF]
arXiv, 2021 Mycobacterium tuberculosis infection can involve all immune system components and can result in different disease outcomes. The antibiotic TB drugs require strict adherence to prevent both disease relapse and mutation of drug- and multidrug-resistant strains.
arxiv
Overall survival of patients with recurrent pancreatic cancer treated with systemic therapy: a retrospective study [PDF]
, 2019 BACKGROUND: Only a few patients with pancreatic ductal adenocarcinoma (PDAC) recurring after curative resection and peri-operative (neoadjuvant and adjuvant) therapy are included in clinical trials of metastatic PDAC.
Gbolahan, Olumide B. +4 more
core +1 more source
Nanoparticle-Assisted Sonosensitizers and Their Biomedical Applications
International Journal of Nanomedicine, 2021 Pengxuan Zhao,1 Youbin Deng,1 Guangya Xiang,2 Yani Liu1 1Department of Medical Ultrasound, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People’s Republic of China; 2School of Pharmacy, Tongji ...
Zhao P, Deng Y, Xiang G, Liu Y
doaj
Biomedicines, 2022 We have previously shown that a radioactive (123I)-analog of methyl 3-(1′-(iodobexyloxy) ethyl-3-devinylpyropheophorbide-a (PET-ONCO), derived from chlorophyll-a can be used for positron emission tomography (PET) imaging of a variety of tumors, including
Joseph C. Cacaccio +3 more
doaj +1 more source
Challenges in constructing genetic instruments for pharmacologic therapies [PDF]
arXiv, 2020 The genes that encode the targets of most therapies do not have rare variants with large-effect or common variants with moderate effects on the biomarker reflecting the pharmacologic action of the corresponding therapy. Therefore, providing genetic target validation for most therapies is challenging.
arxiv
Efficacy of Elaborated Semantic Features Analysis in Aphasia: a quasi-randomised controlled trial [PDF]
, 2019 Background: Word finding difficulty is one of the most common features of aphasia. Semantic Features Analysis (SFA) directly aims to improve word finding in people with aphasia.
Elman R. +13 more
core +1 more source
Combination Therapies for Obesity [PDF]
Metabolic Syndrome and Related Disorders, 2018 The objective of this review is to examine advances in the development of combination therapies for the treatment of obesity beyond diet or lifestyle interventions. Experimental combination pharmacotherapies include combinations of pramlintide and phentermine as well as amylin and bupropion-naltrexone. Incretin and pancreatic hormones generally inhibit
Andres Acosta, Michael Camilleri
openaire +2 more sources