Results 161 to 170 of about 1,144,978 (368)
TRPM8 levels determine tumor vulnerability to channel agonists
Molecular Oncology, EarlyView.TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo +18 more
wiley +1 more source
Molecular Oncology, EarlyView.The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine +10 more
wiley +1 more source
Papers on combinatorial chemistry or solid-phase synthesis from other journals - March 1999
, 1999 openalex +1 more source
Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer
Molecular Oncology, EarlyView.Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte +10 more
wiley +1 more source
Protein-Directed Dynamic Combinatorial Chemistry: An Efficient Strategy in Drug Design. [PDF]
ACS Omega, 2020 Canal-Martín A, Pérez-Fernández R.
europepmc +1 more source
Papers on combinatorial chemistry or solid-phase synthesis from other journals - September 1998
, 1998 openalex +1 more source
NPG Asia MaterialsBiopharmaceutical drugs, such as therapeutic proteins and nucleic acids, are gaining prominence in modern medicine, presenting great opportunities for addressing major diseases that are challenging to treat with traditional small-molecule drugs. However,
Zepeng He +3 more
doaj +1 more source
Molecular Oncology, EarlyView.The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song +11 more
wiley +1 more source
Static Combinatorial Chemistry: A High-Pressure Approach to the Synthesis of Macrocyclic Benzoamide Libraries. [PDF]
ACS Comb Sci, 2020 Pikus G, Tyszka-Gumkowska A, Jurczak J.
europepmc +1 more source