Results 201 to 210 of about 1,152,460 (369)

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

Molecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi, Mirjam Balbisi, Simon Sugár, Lóránd Váncza, Eszter Regős, Ilona Kovalszky, Ibolya Laczó, Tünde Harkó, Gábor Kecskeméti, Zoltán Szabó, Judit Moldvay, László Drahos, Lilla Turiák   +12 more
wiley   +1 more source

Dynamic Combinatorial Chemistry Generates Adaptative Libraries of Glyco-Dyn[n]Arenes That can Be Templated to Produce Anti-Adhesive Glycoconjugates Targeting Pseudomonas aeruginosa. [PDF]

Chemistry
Demontrond F, Pascal Y, Donnier-Maréchal M, Raillon C, Luton B, Tramblais C, Vial L, Gueyrard D, Galia W, Berger E, Géloën A, Cournoyer B, Leclaire J, Vidal S.   +13 more
europepmc   +1 more source

Discovery of Small-Molecule Stabilizers of 14-3-3 Protein-Protein Interactions via Dynamic Combinatorial Chemistry. [PDF]

ACS Med Chem Lett, 2020
Hartman AM, Elgaher WAM, Hertrich N, Andrei SA, Ottmann C, Hirsch AKH.   +5 more
europepmc   +1 more source

Synthesis of Gd[sub 2]O[sub 3]:Eu, Li Phosphor by Modified Combinatorial Chemistry and Its Photoluminescence Behavior [PDF]

, 2002
Joung Kyu Park, Sang Mi Park, Chang Hae Kim, Hee Dong Park, Se Young Choi   +4 more
openalex   +1 more source

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

Molecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza, David James, Emma Creagh, James T. Murray   +3 more
wiley   +1 more source

Dynamic Combinatorial Chemistry Unveils Nsp10 Inhibitors with Antiviral Potential Against SARS-CoV-2. [PDF]

Chemistry
Jumde RP, Jézéquel G, Saramago M, Frank N, Adam S, Cunha MV, Bader CD, Gunesch AP, Köhler NM, Johannsen S, Bousis S, Pietschmann T, Matos RG, Müller R, Arraiano CM, Hirsch AKH.   +15 more
europepmc   +1 more source

Papers on combinatorial chemistry or solid-phase synthesis from other journals - November 2000

, 2000

openalex   +1 more source

Combinatorial Strategies in Biology and Chemistry [PDF]

, 2002
Mark C. Bagley
openalex   +1 more source

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

Target-Directed Dynamic Combinatorial Chemistry Affords Binders of Mycobacterium tuberculosis IspE. [PDF]

ACS Omega
Braun-Cornejo M, Ornago C, Sonawane V, Haupenthal J, Kany AM, Diamanti E, Jézéquel G, Reiling N, Blankenfeldt W, Maas P, Hirsch AKH.   +10 more
europepmc   +1 more source