Results 91 to 100 of about 436,297 (318)

Developing and validating predictive decision tree models from mining chemical structural fingerprints and high–throughput screening data in PubChem

BMC Bioinformatics, 2008
Background Recent advances in high-throughput screening (HTS) techniques and readily available compound libraries generated using combinatorial chemistry or derived from natural products enable the testing of millions of compounds in a matter of days ...
Bryant Stephen H, Wang Yanli, Han Lianyi
doaj   +1 more source

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Molecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi, Jérome Vialaret, Christophe Hirtz, Catherine Alix‐Panabières   +3 more
wiley   +1 more source

Aptamers: A new approach to detection of target molecules [PDF]

فصلنامه ابن سینا, 2016
Background: For more than three decades, antibodies were recognized as the most common class of diagnostic molecules with a wide range of applications, until aptamers became as widespread as antibodies.
M ebrahimi, R Lalavi
doaj  

Bold Feynman diagrams and the Luttinger-Ward formalism via Gibbs measures. Part I: Perturbative approach [PDF]

arXiv, 2018
Many-body perturbation theory (MBPT) is widely used in quantum physics, chemistry, and materials science. At the heart of MBPT is the Feynman diagrammatic expansion, which is, simply speaking, an elegant way of organizing the combinatorially growing number of terms of a certain Taylor expansion.
arxiv  

Maximal Spread of Coherent Distributions: a Geometric and Combinatorial Perspective [PDF]

arXiv, 2020
We discuss some open problems concerning the maximal spread of coherent distributions. We prove a sharp bound on $\mathbb{E}|X-Y|^{\alpha}$ for $(X,Y)$ coherent and $\alpha \le 2$, and establish a novel connection between coherent distributions and such combinatorial objects as bipartite graphs, conjugate partitions and Ferrer diagrams. Our results may
arxiv  

Clinical applications of next‐generation sequencing‐based ctDNA analyses in breast cancer: defining treatment targets and dynamic changes during disease progression

Molecular Oncology, EarlyView.
Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker, Samantha Hasenleithner, Rupert Bartsch, Simon P. Gampenrieder, Daniel Egle, Christian F. Singer, Gabriel Rinnerthaler, Michael Hubalek, Katja Schmitz, Zsuzsanna Bago‐Horvath, Andreas Petzer, Sonja Heibl, Ellen Heitzer, Marija Balic, Michael Gnant   +14 more
wiley   +1 more source

A combinatorial approach to the chemical synthesis and biological evaluation of 3,4,5-trisubstiituted furan-2(5H)-ones [PDF]

Many important natural products contain the furan-2(5H)-one structure. The structure of this molecule lends itself to manipulation using combinatorial techniques due to the presence of more than one site for the attachment of different suhstituents.
Langley, Christopher A.
core   +1 more source

Structure and singly occupied molecular orbital analysis of anionic tautomers of guanine [PDF]

, 2008
Recently we reported the discovery of adiabatically bound anions of guanine which might be involved in the processes of DNA damage by low-energy electrons and in charge transfer through DNA.
Abdoul-Carime, Aflatooni, Aflatooni, Atkins, Bachorz, Berlin, Bixo, Boudaïffa, Cai, Cai, Carhart, Dolgounitcheva, Downs, Downs, Frisch, Gutowski, Haranczyk, Haranczyk, Haranczyk, Haranczyk, Haranczyk, Haranczyk, Hendricks, Henkelman, Hert, Holliday, Humphrey, Kendall, Kendall, Li, Li, Mazurkiewicz, Messer, Periquet, Ptasinska, Sanville, Seidel, Straatsma, Taylor, Tonzani, Wesolowski, Willett, Zakjevskii   +42 more
core   +1 more source

Circulating tumor cells: advancing personalized therapy in small cell lung cancer patients

Molecular Oncology, EarlyView.
Small cell lung cancer (SCLC) is an aggressive form of lung cancer that spreads rapidly to secondary sites such as the brain and liver. Cancer cells circulating in the blood, “circulating tumor cells” (CTCs), have demonstrated prognostic value in SCLC, and evaluating biomarkers on CTCs could guide treatment decisions such as for PARP inhibitors ...
Prajwol Shrestha, Steven Kao, Veronica K. Cheung, Wendy A. Cooper, Nico van Zandwijk, John E. J. Rasko, Dannel Yeo   +6 more
wiley   +1 more source

On physical analysis of phthalocyanine iron (II) using topological descriptor and curve fitting models

Scientific Reports
A new area of applied chemistry called chemical graph theory uses combinatorial techniques to explain the complex interactions between atoms and bonds in chemical systems. This work investigates the use of edge partitions to decipher molecular connection
Muhammad Farhan Hanif, Hasan Mahmood, Shahbaz Ahmad, Mohamed Abubakar Fiidow   +3 more
doaj   +1 more source