Results 101 to 110 of about 172,692 (298)

Centrality Dependence of Charged Particle Multiplicity at Mid-Rapidity in Au+Au Collisions at sqrt(s_NN) = 130 GeV

, 2001
We present a measurement of the pseudorapidity density of primary charged particles near mid-rapidity in Au+Au collisions at sqrt(s_NN) = 130 GeV as a function of the number of participating nucleons. These results are compared to models in an attempt to
A. Białas, A. Budzanowski, A. C. Mignerey, A. Carroll, A. H. Wuosmaa, A. Olszewski, A. Sukhanov, A. Trzupek, B. B. Back, B. Holzman, B. Wadsworth, B. Wosiek, B. Wysłouch, B.B. Back, C. Adler, C. Halliwell, C. Henderson, C. Reed, C. Roland, C. Vale, D. J. Hofman, D. Kharzeev, D. Kharzeev, D. McLeod, D. S. Barton, E. Garcia, E. Johnson, F. Abe, F. L. H. Wolfs, G. A. Heintzelman, G. J. van Nieuwenhuizen, G. Roland, G. S. F. Stephans, H. Pernegger, H. Pernegger, H. Sorge, I. C. Park, J. -L. Tang, J. Katzy, J. L. Kane, J. Michałowski, J. Mülmenstädt, J.E. Elias, K. Adcox, K. Gulbrandsen, K. Woźniak, K.J. Eskola, K.J. Eskola, L. P. Remsberg, L. Rosenberg, M. D. Baker, M. P. Decowski, M. Reuter, M. Stodulski, M.M. Aggarwal, N. George, N. Khan, P. Kulinich, P. Sarin, P. Sawicki, P. Steinberg, R. Bindel, R. Hołyński, R. Nouicer, R. Pak, R. R. Betts, R. Teng, R. Verdier, S. G. Steadman, S. Gushue, S. Manly, V. Franco, W. Busza, W. Kucewicz, W. Skulski, W. T. Lin, X.N. Wang, X.N. Wang   +77 more
core   +1 more source

The subcellular distribution of phosphorylated Y‐box‐binding protein‐1 at S102 in colorectal cancer patients, stratified by KRAS mutational status and clinicopathological features

Molecular Oncology, EarlyView.
This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau, Stephan Forchhammer, Birgit Fehrenbacher, Lejla Mahmutovic, Marcus Scharpf, Gunnar Blumenstock, Martin Schaller, Irina Bonzheim, Shayan Khozooei, Mahmoud Toulany   +9 more
wiley   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Observation of high-Tc superconductivity in inhomogeneous combinatorial ceramics

, 2018
A single-sample synthesis concept based on multi-element ceramic samples can produce a variety of local products. When applied to cuprate superconductors (SC), statistical modelling predicts the occurrence of possible compounds in a concentration range ...
Assenmacher, Wilfried, Hulliger, Jürg, Iranmanesh, Mitra, Kirtley, John R., Mader, Werner, Tohsophon, Thanaporn, Zhigadlo, Nikolai D.   +6 more
core   +1 more source

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source

EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines

Molecular Oncology, EarlyView.
The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche, Renske Imschoot, Béatrice Lintermans, Lode Denolf, Joachim Taminau, Charlotte Fieuws, Geert Berx, Kris Gevaert, Kathleen B. M. Claes   +8 more
wiley   +1 more source

Search for molecular descriptors and computer prediction of biological activity in a series of S-derivatives (1,2,4-triazole-3(2H)-yl)methyl)thiopyrimidines

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki
Most pharmaceutical compounds interact with various molecular compositions in the body, leading to complex biological effects. Furthermore, during biotransformation, they may generate one or more metabolites with potent bioactive properties.
Yu. V. Karpenko, O. I. Panasenko, A. P. Litun   +2 more
doaj   +1 more source

Graph Symmetry Detection and Canonical Labeling: Differences and Synergies [PDF]

, 2012
Symmetries of combinatorial objects are known to complicate search algorithms, but such obstacles can often be removed by detecting symmetries early and discarding symmetric subproblems.
Katebi, Hadi, Markov, Igor L., Sakallah, Karem A.   +2 more
core   +2 more sources

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

Molecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner, Markus Eckstein, Christoph Mark, Matthias W. Beckmann, Arndt Hartmann, Pamela L. Strissel, Reiner Strick   +6 more
wiley   +1 more source

Evaluation and modification of tumor cell isolation techniques from malignant effusions for rapid drug sensitivity testing

Molecular Oncology, EarlyView.
Non‐small cell lung cancer targeted treatment is limited to a few known genetic alterations, with few alternatives in advanced treatment lines. To direct treatment decisions by drug sensitivity testing (DST), this study compared several methods for tumor cell isolation from malignant effusions, pointing to repeated CD45+ cell depletion for effective ...
Navit Mooshayef, Hana Barhom, Sumit Chatterji, Netta Hecht, Oran Warhaftig, Iris Kamer, Oranit Zadok, Jair Bar, Limor Broday, Amir Onn, Michael Peled   +10 more
wiley   +1 more source