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Combinatorial Chemistry Techniques Applied to Nonpeptide lntegrin Antagonists

Current Medicinal Chemistry, 1998
The integrins are cell surface receptors that recognize extracellular matrix adhesive proteins such as fibrinogen, fibronectin, vitronectin, and VCAM-1 (vascular cell adhesion molecule-1). Nonpeptide integrin antagonists designed after the adhesion recognition sequence RGD (Arg-Giy-Asp) not only have displayed efficacy as antithrombotic ...
W J, Hoekstra, B L, Poulter
openaire   +4 more sources

Combinatorial chemistry methods for coating development VI. Correlation of high throughput screening methods with conventional measurement techniques

Progress in Organic Coatings, 2003
Abstract Combinatorial chemistry has proven to be a valuable tool for the development of new compounds. In the pharmaceutical industry, where combinatorial chemistry began, the approach has been instrumental in the high-speed development of new drugs.
Radislav A Potyrailo
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ChemInform Abstract: Resin Capture Techniques in Combinatorial Chemistry

ChemInform, 2000
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A. Chucholowski, M. Nettekoven
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ChemInform Abstract: Combinatorial Chemistry Techniques Applied to Nonpeptide Integrin Antagonists

ChemInform, 1998
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
W. J. HOEKSTRA, B. L. POULTER
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RECAPRetrosynthetic Combinatorial Analysis Procedure:  A Powerful New Technique for Identifying Privileged Molecular Fragments with Useful Applications in Combinatorial Chemistry

Journal of Chemical Information and Computer Sciences, 1998
The use of combinatorial chemistry for the generation of new lead molecules is now a well established strategy in the drug discovery process. Central to the use of combinatorial chemistry is the design and availability of high quality building blocks which are likely to afford hits from the libraries that they generate.
Xiao Qing Lewell   +3 more
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Direct-Injection NMR (DI-NMR):  A Flow NMR Technique for the Analysis of Combinatorial Chemistry Libraries

Journal of Combinatorial Chemistry, 2000
A new tool for analyzing compound libraries by NMR has been developed. Aliquots of solution-state samples (between 120 and 350 microL) are directly injected, using a standard liquids handler, into an NMR (LC-NMR) flow probe. Automated NMR software tracks--and suppresses--intense signals arising from the nondeuterated solvents used (if any) and acquires
P A, Keifer   +6 more
openaire   +2 more sources

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