Results 191 to 200 of about 16,727 (234)

Exploring and expanding the chemical multiverse of peptides. [PDF]

Chem Sci
López-López E, Sánchez-Castañeda JP, Martinez-Cortés MS, de la Fuente-Nunez C, Medina-Franco JL.   +4 more
europepmc   +1 more source

Chemputer and chemputation-A universal chemical compound synthesis machine. [PDF]

Proc Natl Acad Sci U S A
Cronin L, Pagel S, Sharma A.
europepmc   +1 more source

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Combinatorial Chemistry Techniques Applied to Nonpeptide lntegrin Antagonists

Current Medicinal Chemistry, 1998
The integrins are cell surface receptors that recognize extracellular matrix adhesive proteins such as fibrinogen, fibronectin, vitronectin, and VCAM-1 (vascular cell adhesion molecule-1). Nonpeptide integrin antagonists designed after the adhesion recognition sequence RGD (Arg-Giy-Asp) not only have displayed efficacy as antithrombotic ...
W J, Hoekstra, B L, Poulter
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ChemInform Abstract: Resin Capture Techniques in Combinatorial Chemistry

ChemInform, 2000
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A. Chucholowski, M. Nettekoven
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ChemInform Abstract: Combinatorial Chemistry Techniques Applied to Nonpeptide Integrin Antagonists

ChemInform, 1998
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
W. J. HOEKSTRA, B. L. POULTER
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RECAPRetrosynthetic Combinatorial Analysis Procedure:  A Powerful New Technique for Identifying Privileged Molecular Fragments with Useful Applications in Combinatorial Chemistry

Journal of Chemical Information and Computer Sciences, 1998
The use of combinatorial chemistry for the generation of new lead molecules is now a well established strategy in the drug discovery process. Central to the use of combinatorial chemistry is the design and availability of high quality building blocks which are likely to afford hits from the libraries that they generate.
X Q, Lewell, D B, Judd, S P, Watson, M M, Hann   +3 more
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Analytical Techniques for Combinatorial Chemistry:  Quantitative Infrared Spectroscopic Measurements of Deuterium-Labeled Protecting Groups

Journal of the American Chemical Society, 1996
Infrared microspectroscopy has been developed as a powerful, nondestructive technique for the quantitative analysis of solid-phase, resin-bound chemical reactions. The synthesis and/or application of deuterium isotope containing protecting groups, including acetyl-d3 chloride, benzoyl-d5 chloride, and 2-[[[(tert-butyl-d9)oxy]carbonyl]oximino]-2 ...
Keith Russell, Derek C. Cole, Frances M. McLaren, Don. E. Pivonka   +3 more
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Combinatorial chemistry synthesis techniques

Proceedings of the 19th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. 'Magnificent Milestones and Emerging Opportunities in Medical Engineering' (Cat. No.97CH36136), 2002
As pharmaceutical companies race to find new and novel drugs faster, the tools of combinatorial chemistry are increasingly playing a larger role. Chemists can now prepare hundreds or thousands of analogs simultaneously to reveal structure-activity relationships (SAR) all at once and potentially shorten the discovery process for new drugs by years.
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