Results 271 to 280 of about 436,297 (318)

Combinatorial chemistry techniques applied to nonpeptide integrin antagonists.

Current Medicinal Chemistry, 1998
The integrins are cell surface receptors that recognize extracellular matrix adhesive proteins such as fibrinogen, fibronectin, vitronectin, and VCAM-1 (vascular cell adhesion molecule-1).
WJ Hoekstra, Poulter Bl
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Investigation of Solid-Phase Peptide Synthesis by the Near-Infrared Multispectral Imaging Technique:  A Detection Method for Combinatorial Chemistry

Analytical Chemistry, 1999
A near-infrared (NIR) multispectral imaging spectrometer was used to monitor solid-phase peptide synthesis. This imaging spectrometer has fast scanning ability and high sensitivity because it is based on an acousto-optic tunable filter and a NIR InGaAs focal plane array camera.
Marc Fischer, Chieu D. Tran
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COMBINATORIAL CHEMISTRY

Chemical & Engineering News Archive, 1997
S. Borman
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Analytical Techniques in Combinatorial Chemistry Edited by Michael Swartz. Marcel Dekker, New York. 2000. xii + 301 pp. 15.5 × 23.5 cm. ISBN 0-8247-1939-5. $150.00.

Journal of Medicinal Chemistry, 2000
Robert G. Gentles
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Rapid Lead Identication of Inhibitors of Adenine Nucleotide Translocase: A Case Study of Applying Combinatorial Chemistry Techniques in Drug Discovery

, 2008
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Application of Pictet-Spengler Reaction to Indole-Based Alkaloids Containing Tetrahydro-β-carboline Scaffold in Combinatorial Chemistry.

ACS Combinatorial Science, 2017
Indole-based alkaloids are well-known in the literature for their diverse biological properties. Polysubstituted optically active tetrahydro-β-carboline derivatives functionalized on C-1 position are the common structural motif in most of the indole ...
R. N. Rao, Barnali Maiti, K. Chanda
semanticscholar   +1 more source

Fuzzy electron density fragments in macromolecular quantum chemistry, combinatorial quantum chemistry, functional group analysis, and shape-activity relations.

Accounts of Chemical Research, 2014
Conspectus Just as complete molecules have no boundaries and have "fuzzy" electron density clouds approaching zero density exponentially at large distances from the nearest nucleus, a physically justified choice for electron density fragments exhibits ...
P. Mezey
semanticscholar   +1 more source

Dynamic combinatorial chemistry employing boronic acids/boronate esters leads to potent oxygenase inhibitors.

Angewandte Chemie, 2012
The application of dynamic reactions is a promising approach for the discovery of small-molecule ligands for proteins. To date, however, this method is limited by the few appropriate reactions and the techniques used for the analysis of protein– ligand ...
M. Demetriades, Ivanhoe K. H. Leung, R. Chowdhury, M. Chan, M. McDonough, K. Yeoh, Ya-min Tian, T. Claridge, P. Ratcliffe, E. Woon, C. Schofield   +10 more
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Combinatorial Solid-Phase Synthesis of Aromatic Oligoamides: A Research-Based Laboratory Module for Undergraduate Organic Chemistry

, 2016
A five-week, research-based experiment suitable for second-semester introductory organic laboratory students is described. Each student designs, prepares, and analyzes a combinatorial array of six aromatic oligoamides.
Amelia A. Fuller
semanticscholar   +1 more source

Combinatorial chemistry: libraries from libraries, the art of the diversity-oriented transformation of resin-bound peptides and chiral polyamides to low molecular weight acyclic and heterocyclic compounds.

Journal of Organic Chemistry, 2004
Combinatorial chemistry has deeply impacted the drug discovery process by accelerating the synthesis and screening of large numbers of compounds having therapeutic and/or diagnostic potential.
A. Nefzi, J. Ostresh, Yongping Yu, R. Houghten   +3 more
semanticscholar   +1 more source