Results 81 to 90 of about 74,437 (278)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Finding combinatorial histone code by semi-supervised biclustering
BMC Genomics, 2012 Background Combinatorial histone modification is an important epigenetic mechanism for regulating chromatin state and gene expression. Given the rapid accumulation of genome-wide histone modification maps, there is a pressing need for computational ...
Teng Li, Tan Kai
doaj +1 more source
Repairable Block Failure Resilient Codes
, 2014 In large scale distributed storage systems (DSS) deployed in cloud computing, correlated failures resulting in simultaneous failure (or, unavailability) of blocks of nodes are common.
Calis, Gokhan, Koyluoglu, O. Ozan
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Searching ChIP-seq genomic islands for combinatorial regulatory codes in mouse embryonic stem cells
BMC Genomics, 2011 Background To facilitate deciphering underlying transcriptional regulatory circuits in mouse embryonic stem (ES) cells, recent ChIP-seq data provided genome-wide binding locations of several key transcription factors (TFs); meanwhile, existing efforts ...
Chen Gong, Zhou Qing
doaj +1 more source
Construction of Codes for Network Coding [PDF]
, 2010 Based on ideas of K\"otter and Kschischang we use constant dimension subspaces as codewords in a network. We show a connection to the theory of q-analogues of a combinatorial designs, which has been studied in Braun, Kerber and Laue as a purely ...
Elsenhans, Andreas-Stephan +2 more
core
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Combinatorial properties of codes with degree n
European Journal of Combinatorics, 2003 The authors study the very thin codes of degree \(n\). The combinatorial properties of synchronizing codes are extended to the codes of degree \(n\geq 2\). By using a very thin code of degree \(n\), it is shown that it is possible to localize the \(n\) positions of the coded message and that the decoding of the message must pass through one of these ...
Liang Zhang 0008 +2 more
openaire +2 more sources