Results 81 to 90 of about 692,674 (293)
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Key Distribution System Based on Hadamard Designs
Моделирование и анализ информационных систем, 2019 The problem of key distribution in a community for providing secure communication between its participants is studied. To solve this problem, key predistribution systems can be used, in which each user receives some key information that can later be used
Vladimir M. Deundyak, Alexey A. Taran
doaj +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Finding combinatorial histone code by semi-supervised biclustering
BMC Genomics, 2012 Background Combinatorial histone modification is an important epigenetic mechanism for regulating chromatin state and gene expression. Given the rapid accumulation of genome-wide histone modification maps, there is a pressing need for computational ...
Teng Li, Tan Kai
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Combinatorial properties of codes with degree n
European Journal of Combinatorics, 2003 The authors study the very thin codes of degree \(n\). The combinatorial properties of synchronizing codes are extended to the codes of degree \(n\geq 2\). By using a very thin code of degree \(n\), it is shown that it is possible to localize the \(n\) positions of the coded message and that the decoding of the message must pass through one of these ...
Liang Zhang 0008 +2 more
openaire +3 more sources
Demi-matroids from codes over finite Frobenius rings
, 2015 We present a construction of demi-matroids, a generalization of matroids, from linear codes over finite Frobenius rings, as well as a Greene-type identity for rank generating functions of demi-matroids.
Westerbäck, Thomas, +4 more
core +1 more source
Dynamic Combinatorial Libraries: From Exploring Molecular Recognition to Systems Chemistry [PDF]
, 2013 Dynamic combinatorial chemistry (DCC) is a subset of combinatorial chemistry where the library members interconvert continuously by exchanging building blocks with each other.
Otto, Sijbren, +9 more
core +1 more source
Searching ChIP-seq genomic islands for combinatorial regulatory codes in mouse embryonic stem cells
BMC Genomics, 2011 Background To facilitate deciphering underlying transcriptional regulatory circuits in mouse embryonic stem (ES) cells, recent ChIP-seq data provided genome-wide binding locations of several key transcription factors (TFs); meanwhile, existing efforts ...
Chen Gong, Zhou Qing
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Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source