Results 121 to 130 of about 9,474,722 (291)
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Matrix bids in combinatorial auctions: expressiveness and micro-economic properties [PDF]
A combinatorial auction is an auction where multiple items are for sale simultaneously to a set of buyers. Furthermore, buyers are allowed to place bids on subsets of the available items.
Spieksma, F.C.R. +2 more
core
NanophotonicsFinding an optimal device structure in the vast combinatorial design space of freeform nanophotonic design has been an enormous challenge. In this study, we propose physics-informed reinforcement learning (PIRL) that combines the adjoint-based method ...
Park Chaejin +8 more
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Simple Combinatorial Optimisation Cost Games [PDF]
In this paper we introduce the class of simple combinatorial optimisation cost games, which are games associated to {0, 1}-matrices.A coalitional value of a combinatorial optimisation game is determined by solving an integer program associated with this ...
Velzen, S. van
core
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Introduction to combinatorial chemistry and technologies : principles and methods
, 2007 An introduction to the huse of high throughput technologies (HTS, combinatorial chemistry, virtual screening, etc) in various areas was presented and ...
Pierfausto Seneci
core +2 more sources
Guide RNA structure design enables combinatorial CRISPRa programs for biosynthetic profiling
Nature CommunicationsEngineering metabolism to efficiently produce chemicals from multi-step pathways requires optimizing multi-gene expression programs to achieve enzyme balance.
Jason Fontana +10 more
doaj +1 more source
Combinatorial problems in repeated measurements designs
Discrete Mathematics, 1989 In the recent past a number of papers on design of experiments have considered the structure of designs with certain desirable properties. In a repeated measurements designs (RMD) there are t treatments, n experimental units and the experiment lasts for p periods. Each experimental unit receives one treatment during each period.
openaire +2 more sources