Results 101 to 110 of about 287,386 (283)

Accelerated Driving-Training-Based Optimization for Solving Constrained Bi-Objective Stochastic Optimization Problems

Mathematics
The constrained bi-objective stochastic optimization problem (CBSOP) considers the optimization problem with stochastic bi-objective functions subject to deterministic constraints.
Shih-Cheng Horng, Shieh-Shing Lin
doaj   +1 more source

Combinatorial design of nanoparticles for pulmonary mRNA delivery and genome editing. [PDF]

Nat Biotechnol, 2023
Li B, Manan RS, Liang SQ, Gordon A, Jiang A, Varley A, Gao G, Langer R, Xue W, Anderson D.   +9 more
europepmc   +1 more source

A Review of the L-Band Auction [PDF]

In May 2008, Ofcom’s L-band auction concluded. This was Ofcom’s second combinatorial clock auction. The auction used an innovative format intended to encourage an efficient assignment of the 17 lots. Eight bidders competed for the lots. In sharp contrast
Peter Cramton
core  

Combinatorial Diffusion Auction Design

CoRR
Diffusion auction design for combinatorial settings is a long-standing challenge. One difficulty is that we cannot directly extend the solutions for simpler settings to combinatorial settings (like extending the Vickrey auction to VCG in the traditional settings).
Xuanyu Li, Miao Li, Yuhan Cao 0003, Dengji Zhao   +3 more
openaire   +2 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Sobre o uso de métodos quimiométricos em química combinatória The use of chemometric methods on combinatorial chemistry

Química Nova, 2000
Combinatorial chemistry has emerged as a tool to circumvent a major problem of pharmaceutical industries to discover new lead compounds. A rapid and massive evaluation of a myriad of newly synthesised compounds can be carried out. Combinatorial synthesis
Andrei Leitão, Carlos A. Montanari, Claudio L. Donnici   +2 more
doaj   +1 more source

Combinatorial design of a sialic acid imprinted binding site exploring a dual ion receptor approach. [PDF]

RSC Adv, 2021
Mavliutova L, Verduci E, Sellergren B.
europepmc   +1 more source

A Review of the 10-40 GHz Auction [PDF]

In February 2008, Ofcom’s 10-40 GHz auction concluded. This was Ofcom’s first combinatorial clock auction. The auction used an innovative format intended to encourage an efficient assignment of the 27 lots.
Peter Cramton
core