Results 101 to 110 of about 9,474,722 (291)
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
MathematicsThe constrained bi-objective stochastic optimization problem (CBSOP) considers the optimization problem with stochastic bi-objective functions subject to deterministic constraints.
Shih-Cheng Horng, Shieh-Shing Lin
doaj +1 more source
Virtual Screening in Lead Discovery: A Viewpoint
Molecules, 2002 Virtual screening (VS) methods have emerged as an adaptive response to massive throughput synthesis and screening technologies. Based on the structure-permeability paradigm, the Lipinski rule of five has become a standard property filtering protocol for ...
Tudor Ionel Oprea
doaj +1 more source
ACE configurator for ELISpot: optimizing combinatorial design of pooled ELISpot assays with an epitope similarity model. [PDF]
Brief Bioinform, 2023 Lee JS +4 more
europepmc +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Efficient Combinatorial Exchanges [PDF]
We investigate combinatorial exchanges as a generalization of combinatorial auctions and bilateral trades, where the multiple commodities to be traded are possessed by participants and a central planner as endowments. Private values, risk neutrality, and
Hitoshi Matsushima
core
Covering the Combinatorial Design Space of Multiplex CRISPR/Cas Experiments in Plants. [PDF]
Front Plant Sci, 2022 Van Huffel K +3 more
europepmc +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Combinatorial design-based quasi-cyclic LDPC codes with girth eight
Digital Communications and Networks, 2018 This paper presents a novel regular Quasi-Cyclic (QC) Low Density Parity Check (LDPC) codes with column-weight three and girth at least eight. These are designed on the basis of combinatorial design in which subsets applied for the construction of ...
Sina Vafi, Narges Rezvani Majid
doaj +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source