Results 91 to 100 of about 9,474,722 (291)

Combinatorial Markets for Efficient Electricity Management

, 2005
The deregulation of the electricity industry in many countries has created a number of marketplaces in which producers and consumers can operate in order to more effectively manage and meet their energy needs. To this end, this paper develops a new model
Jennings, N. R., Penya, Y.K.
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Combinatorial solid-phase synthesis of 4,6-diaryl and 4-aryl, 6-alkyl-1,3,5-triazines and their application to efficient biofuel production

, 2012
10.1021/co300007aACS Combinatorial Science147395 ...
Kim, Jaoon Y. H., Lee, Y., Chang, Young-Tae, Ha, H.-H., Lee, Woo Sirl, Lee, J.W., Chang, Y.-T., Bork, J.T., Lee, W.S., Vendrell, M., Ha, Hyung-Ho, Kim, J.Y.H., Lee, Y, Bork, Jacqueline T., Lee, Jae Wook, Vendrell, Marc   +15 more
core   +1 more source

Phosphodiesterase Inhibition and Immunotropic Activity of Dipyridamole Dynamic Derivatives

Current Issues in Molecular Biology
Introduction. Many pharmacological properties of dipyridamole (DIP) are associated with its ability to inhibit phosphodiesterases (PDEs). Actually, DIP has interesting properties like antiviral for influenza, SARS-2 COVID-19, and herpesviruses.
Artur Martynov, Boris Farber, Alexander Katz   +2 more
doaj   +1 more source

Rationally reduced libraries for combinatorial pathway optimization minimizing experimental effort

Nature Communications, 2016
Rational design in metabolic engineering is often difficult and limited to small screens, favouring construction of compressed smart libraries. Here the authors introduce RedLibs, an algorithm to design combinatorial RBS libraries to allow pathway ...
Markus Jeschek, Daniel Gerngross, Sven Panke   +2 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Optimizing enzyme thermostability by combining multiple mutations using protein language model

mLife
Optimizing enzyme thermostability is essential for advancements in protein science and industrial applications. Currently, (semi‐)rational design and random mutagenesis methods can accurately identify single‐point mutations that enhance enzyme ...
Jiahao Bian, Pan Tan, Ting Nie, Liang Hong, Guang‐Yu Yang   +4 more
doaj   +1 more source

Combinatorial design of nanoparticles for pulmonary mRNA delivery and genome editing. [PDF]

Nat Biotechnol, 2023
Li B, Manan RS, Liang SQ, Gordon A, Jiang A, Varley A, Gao G, Langer R, Xue W, Anderson D.   +9 more
europepmc   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Combinatorial design of ionizable lipid nanoparticles for muscle-selective mRNA delivery with minimized off-target effects. [PDF]

Proc Natl Acad Sci U S A, 2023
Chen J, Xu Y, Zhou M, Xu S, Varley AJ, Golubovic A, Lu RXZ, Wang KC, Yeganeh M, Vosoughi D, Li B.   +10 more
europepmc   +1 more source