Results 81 to 90 of about 287,386 (283)
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing autoimmune disease of the central nervous system. High‐dose intravenous methylprednisolone (IVMP) is the standard first‐line therapy for acute attacks, although some patients remain refractory.
Wataru Horiguchi +5 more
wiley +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Probabilistic Existence of Large Sets of Designs
, 2020 A new probabilistic technique for establishing the existence of certain regular combinatorial structures has been recentlyintroduced by Kuperberg, Lovett, and Peled (STOC 2012).
Lovett, Shachar +2 more
core
Strongly Polynomial Primal-Dual Algorithms for Concave Cost Combinatorial Optimization Problems [PDF]
, 2012 We introduce an algorithm design technique for a class of combinatorial optimization problems with concave costs. This technique yields a strongly polynomial primal-dual algorithm for a concave cost problem whenever such an algorithm exists for the fixed-
Magnanti, Thomas L., Stratila, Dan
core +2 more sources
A Bayesian Clearing Mechanism for Combinatorial Auctions
, 2018 We cast the problem of combinatorial auction design in a Bayesian framework in order to incorporate prior information into the auction process and minimize the number of rounds to convergence.
Brero, Gianluca, Lahaie, Sébastien
core +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Optimizing enzyme thermostability by combining multiple mutations using protein language model
mLifeOptimizing enzyme thermostability is essential for advancements in protein science and industrial applications. Currently, (semi‐)rational design and random mutagenesis methods can accurately identify single‐point mutations that enhance enzyme ...
Jiahao Bian +4 more
doaj +1 more source
Phosphodiesterase Inhibition and Immunotropic Activity of Dipyridamole Dynamic Derivatives
Current Issues in Molecular BiologyIntroduction. Many pharmacological properties of dipyridamole (DIP) are associated with its ability to inhibit phosphodiesterases (PDEs). Actually, DIP has interesting properties like antiviral for influenza, SARS-2 COVID-19, and herpesviruses.
Artur Martynov +2 more
doaj +1 more source
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Rationally reduced libraries for combinatorial pathway optimization minimizing experimental effort
Nature Communications, 2016 Rational design in metabolic engineering is often difficult and limited to small screens, favouring construction of compressed smart libraries. Here the authors introduce RedLibs, an algorithm to design combinatorial RBS libraries to allow pathway ...
Markus Jeschek +2 more
doaj +1 more source