Results 41 to 50 of about 184,660 (274)

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon   +9 more
wiley   +1 more source

On distance labelings of 2-regular graphs

open access: yesElectronic Journal of Graph Theory and Applications, 2021
Let G  be a graph with |V(G)| vertices and ψ :  V(G) → {1, 2, 3, ... , |V(G)|} be a bijective function. The weight of a vertex v ∈ V(G) under ψ is wψ(v) = ∑u ∈ N(v)ψ(u).  The function ψ is called a distance magic labeling of G, if wψ(v) is a constant for
Anak Agung Gede Ngurah   +1 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Total vertex irregularity strength for trees with many vertices of degree two

open access: yesElectronic Journal of Graph Theory and Applications, 2020
For a simple graph G = (V,E), a mapping φ : V ∪ E → {1,2,...,k} is defined as a vertex irregular total k-labeling of G if for every two different vertices x and y, wt(x) ≠ wt(y), where wt(x) = φ(x)+ Σ􏰄xy∈E(G) φ(xy).
Rinovia Simanjuntak   +2 more
doaj   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

open access: yesFEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas   +6 more
wiley   +1 more source

Faces of Birkhoff Polytopes [PDF]

open access: yes, 2013
The Birkhoff polytope B(n) is the convex hull of all (n x n) permutation matrices, i.e., matrices where precisely one entry in each row and column is one, and zeros at all other places.
Paffenholz, Andreas
core  

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

A priority tree based coordination method for intelligent and connected vehicles at unsignalized intersections

open access: yesIET Intelligent Transport Systems, 2021
Intelligent and connected vehicles are believed to be the future solution to traffic management, especially in highly challenging areas such as intersections.
Lv Dongxin   +4 more
doaj   +1 more source

Determining finite connected graphs along the quadratic embedding constants of paths

open access: yesElectronic Journal of Graph Theory and Applications, 2021
The QE constant of a finite connected graph G, denoted by QEC(G), is by definition the maximum of the quadratic function associated to the distance matrix on a certain sphere of codimension two.
Edy Tri Baskoro, Nobuaki Obata
doaj   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

open access: yesFEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

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