Results 161 to 170 of about 63,688 (308)

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Making Robust Decisions in Discrete Optimization Problems as a Game against Nature [PDF]

open access: yes
In this paper a discrete optimization problem under uncertainty is discussed. Solving such a problem can be seen as a game against nature. In order to choose a solution, the minmax and minmax regret criteria can be applied.
Adam Kasperski
core  

Stochastic Combinatorial Optimization with Risk [PDF]

open access: yes, 2008
We consider general combinatorial optimization problems that can be formulated as minimizing the weight of a feasible solution wT x over an arbitrary feasible set.
Nikolova, Evdokia
core  

The Role of Experimental Noise in a Hybrid Classical-Molecular Computer to Solve Combinatorial Optimization Problems. [PDF]

open access: yesACS Cent Sci, 2023
Krasecki VK   +13 more
europepmc   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

Third ALIO-EURO meeting on Applied Combinatorial Optimization-Discrete Applied Mathematics [PDF]

open access: yes, 2002
Numero speciale di Discrte Applied Mathematics contenente le versioni definitive dei lavori selezionati tra quelli presentati al Convegno ALIO-EURO su Applied Combinatorial Optimization tenutosi a Erice nel Novembre ...
MAFFIOLI, FRANCESCO, MALUCELLI, FEDERICO
core  

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

open access: yesFEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková   +3 more
wiley   +1 more source

Optimization models of rail transportation under the financial crisis [PDF]

open access: yes
This paper proposes an analysis of the most used models to optimize the rail transportation. Are presented a series of optimization models of labor efficiency in this sector, but also elements that gives the information on the competitiveness of this ...
Mariana BALAN, Gheorghe-Stelian BALAN
core  

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