Results 141 to 150 of about 63,688 (308)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Optimizing Genetic Algorithm by Implementation of An Enhanced Selection Operator

JOIV: International Journal on Informatics Visualization
The Traveling Salesman Problem (TSP) represents an extensively researched challenge in combinatorial optimization. Genetic Algorithms (GAs), recognized for their nature-inspired approach, stand as potent heuristics for resolving combinatorial ...
Mohammed BinJubier, Mohd Arfian Ismail, Muhaini Othman, Shahreen Kasim, Hidra Amnur   +4 more
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

A hybrid neural combinatorial optimization framework assisted by automated algorithm design

Complex & Intelligent Systems
In recent years, the application of Neural Combinatorial Optimization (NCO) techniques in Combinatorial Optimization (CO) has emerged as a popular and promising research direction.
Liang Ma, Xingxing Hao, Wei Zhou, Qianbao He, Ruibang Zhang, Li Chen   +5 more
doaj   +1 more source

Combinatorial optimization and spatial remodeling of CYPs to control product profile. [PDF]

Metab Eng, 2023
Yang J, Liu Y, Zhong D, Xu L, Gao H, Keasling JD, Luo X, Chou HH.   +7 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Beyond Neural Solvers: A Critical Review of Machine Learning for Combinatorial Optimization

Mathematics
Combinatorial optimization is a key component in critical decision problems such as routing, scheduling, network design, and graph optimization. Although combinatorial optimization methods, including exact algorithms, approximation methods, constraint ...
Mostafa E. A. Ibrahim, Alaa E. S. Ahmed, Yassine Daadaa   +2 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Semidefinite Programming in Combinatorial and Polynomial Optimization [PDF]

, 2008
In the recent years semidefinite programming has become a widely used tool for designing better efficient algorithms for approximating hard combinatorial optimization problems and, more generally, polynomial optimization problems, which deal with ...
Laurent, Monique, Laurent, M. (Monique)
core  

Efficient combinatorial optimization by quantum-inspired parallel annealing in analogue memristor crossbar. [PDF]

Nat Commun, 2023
Jiang M, Shan K, He C, Li C.
europepmc   +1 more source