Results 131 to 140 of about 1,967,671 (302)
FEBS Open Bio, EarlyView.Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar +4 more
wiley +1 more source
Research on a new multiobjective combinatorial optimization algorithm
, 2004 An real world engineering design problem is usually with multiple conflicting objectives, and it is easily lead to the difficulty to optimize these objectives at the same time. Multiobjective combinatorial optimization is not only an open theory problem,
Qin YF(秦永法), Zhao MY(赵明扬)
core +1 more source
Combinatorial Optimization Problems Arising from Interactive Congestion Situations
, 2011 The purpose of this chapter is to survey the research area of game theory applied to congestion situations, where a group of autonomous agents, interacting in a discrete system that underlies various types of combinatorial optimization problems, try to ...
Gourvès, Laurent, Moretti, Stefano
core
Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids
FEBS Open Bio, EarlyView.Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão +3 more
wiley +1 more source
Matrix bids in combinatorial auctions: expressiveness and micro-economic properties [PDF]
A combinatorial auction is an auction where multiple items are for sale simultaneously to a set of buyers. Furthermore, buyers are allowed to place bids on subsets of the available items.
Spieksma, F.C.R. +2 more
core
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
FEBS Open Bio, EarlyView.Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill +6 more
wiley +1 more source
A hybrid neural combinatorial optimization framework assisted by automated algorithm design
Complex & Intelligent SystemsIn recent years, the application of Neural Combinatorial Optimization (NCO) techniques in Combinatorial Optimization (CO) has emerged as a popular and promising research direction.
Liang Ma +5 more
doaj +1 more source
Optimizing Genetic Algorithm by Implementation of An Enhanced Selection Operator
JOIV: International Journal on Informatics VisualizationThe Traveling Salesman Problem (TSP) represents an extensively researched challenge in combinatorial optimization. Genetic Algorithms (GAs), recognized for their nature-inspired approach, stand as potent heuristics for resolving combinatorial ...
Mohammed BinJubier +4 more
doaj +1 more source
MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis
FEBS Open Bio, EarlyView.MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss +7 more
wiley +1 more source