Results 151 to 160 of about 36,738 (263)

Clinical Spectrum and Outcomes of SOX1 Antibody‐Associated Paraneoplastic Neurological Syndromes: A Chinese Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background SOX1 antibody‐positive paraneoplastic neurological syndromes (PNS) exhibit significant population‐specific clinical heterogeneity. While Western cohorts predominantly manifest Lambert‐Eaton myasthenic syndrome (65%–80%), comprehensive clinical characterization and treatment response data in Asian populations remain critically ...
Jin‐Long Ye, Zu‐Ying Kuang, Bo Li, Meng‐Qiu Pan, Li‐Hua Zhou, Yang‐Yang Dai, Si‐Fen Xie, Xian‐Guang Lin, Ye‐Peng Hu, Li‐Hong Jiang, Zhan‐Hang Wang, Wei‐Jing Zhang   +11 more
wiley   +1 more source

Combinatorial optimization enhanced by shallow quantum circuits with 104 superconducting qubits. [PDF]

Natl Sci Rev
Zhu X, Zou Z, Jin F, Mosharev P, Luo M, Wu Y, Chen J, Zhang C, Gao Y, Wang N, Zou Y, Zhang A, Shen F, Bao Z, Zhu Z, Zhong J, Cui Z, Han Y, He Y, Wang H, Yang JN, Wang Y, Shen J, Liu G, Song Z, Deng J, Dong H, Zhang P, Song C, Wang Z, Li H, Guo Q, Yung MH, Wang H.   +33 more
europepmc   +1 more source

High-performance combinatorial optimization based on classical mechanics. [PDF]

Sci Adv, 2021
Goto H, Endo K, Suzuki M, Sakai Y, Kanao T, Hamakawa Y, Hidaka R, Yamasaki M, Tatsumura K.   +8 more
europepmc   +1 more source

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

Modifying VEGF-A mRNA by combinatorial optimization to enhance therapeutic efficacy for myocardial infarction. [PDF]

Sci Rep
Wang W, Zhan Z, Chen L, Wang Z, Wang L, Liu S, Lin Z, Yang Z, Wang K.   +8 more
europepmc   +1 more source

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

Analog optical computer for AI inference and combinatorial optimization. [PDF]

Nature
Kalinin KP, Gladrow J, Chu J, Clegg JH, Cletheroe D, Kelly DJ, Rahmani B, Brennan G, Canakci B, Falck F, Hansen M, Kleewein J, Kremer H, O'Shea G, Pickup L, Rajmohan S, Rowstron A, Ruhle V, Braine L, Khedekar S, Berloff NG, Gkantsidis C, Parmigiani F, Ballani H.   +23 more
europepmc   +1 more source

Towards improving edge quality using combinatorial optimization and a novel skeletonize algorithm. [PDF]

BMC Med Imaging, 2021
Arnold M, Speidel S, Hattab G.
europepmc   +1 more source

Complementarity of Long‐Reads and Optical Mapping in Parkinson's Disease for Structural Variants

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Long‐read sequencing and optical genome mapping technologies have the ability to detect large and complex structural variants. This has led to the discovery of novel pathogenic variants in neurodegenerative movement disorders. Thus, we aimed to systematically compare the SV detection capabilities of OGM and ONT in Parkinson's disease.
André Fienemann, Theresa Lüth, Susen Schaake, Carolin Gabbert, Marius Möller, Hauke Busch, Katja Lohmann, Jonas A. Gustafson, Danny E. Miller, Kensuke Daida, Manabu Funayama, Nobutaka Hattori, Samia Ben Sassi, Faycel Hentati, Matthew J. Farrer, Kristian K. Ullrich, Christine Klein, Joanne Trinh   +17 more
wiley   +1 more source

Pushing the boundary of quantum advantage in hard combinatorial optimization with probabilistic computers. [PDF]

Nat Commun
Chowdhury S, Aadit NA, Grimaldi A, Raimondo E, Raut A, Lott PA, Mentink JH, Rams MM, Ricci-Tersenghi F, Chiappini M, Theogarajan LS, Srimani T, Finocchio G, Mohseni M, Camsari KY.   +14 more
europepmc   +1 more source