Results 151 to 160 of about 63,688 (308)

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

A general ant colony model to solve combinatorial optimization problems

Revista Colombiana de Computación, 2001
An Ants System is an artificial system based on the behavior of real ant colonies, which is used to solve combinatorial problems. Keywords: Combinatorial Optimization Problem,AntSystem, the Graph Partitioning and The Traveling Salesman Problems.
José Aguilar
doaj  

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Algoritmo de otimização combinatorial: uma proposta híbrida utilizando os algoritmos simulated annealing e genético em ambiente multiprocessado [PDF]

, 2005
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Ciência da Computação.A busca por soluções de problemas envolvendo otimização combinatorial tem sido motivo de estudos e pesquisas há muito ...
Bona, Anderson Andrei de
core  

Testing a vaccine candidate against Hepatitis C virus designed by combinatorial optimization. [PDF]

Sci Rep, 2023
Malaina I, Martinez L, Salcines-Cuevas D, Teran-Navarro H, Ocejo-Vinyals JG, Gonzalez-Lopez E, Soriano V, Ubeda M, Perez Pinilla MB, Martinez de la Fuente I, Alvarez-Dominguez C.   +10 more
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Combinatorial Optimization

Combinatorial optimization deals with optimization problems defined on polyhedral constraints or discrete structures such as graphs and networks. In the past thirty years the topic has developed into a rich mathematical discipline with many connections to other fields of mathematics such as combinatorics, group theory, geometry of numbers, convex ...
Dalzell, Alexander M., McArdle, Sam, Salton, Grant, Wang, Samson, Brandão, Fernando G. S. L., Berta, Mario Andrea, Bienias, Przemyslaw, Chen, Chi-Fang, Gilyén, András, Hann, Connor T., Kastoryano, Michael J., Khabiboulline, Emil T., Kubica, Aleksander   +12 more
openaire   +3 more sources

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Designing Ising machines with higher order spin interactions and their application in solving combinatorial optimization. [PDF]

Sci Rep, 2023
Bashar MK, Shukla N.
europepmc   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source