Results 151 to 160 of about 211,682 (273)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Simplicity and Complexity in Combinatorial Optimization. [PDF]

Entropy (Basel)
Dingle K, Hutter M.
europepmc   +1 more source

Towards improving edge quality using combinatorial optimization and a novel skeletonize algorithm. [PDF]

BMC Med Imaging, 2021
Arnold M, Speidel S, Hattab G.
europepmc   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Analog optical computer for AI inference and combinatorial optimization. [PDF]

Nature
Kalinin KP, Gladrow J, Chu J, Clegg JH, Cletheroe D, Kelly DJ, Rahmani B, Brennan G, Canakci B, Falck F, Hansen M, Kleewein J, Kremer H, O'Shea G, Pickup L, Rajmohan S, Rowstron A, Ruhle V, Braine L, Khedekar S, Berloff NG, Gkantsidis C, Parmigiani F, Ballani H.   +23 more
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Multi-State Probabilistic Computing Using Floating-Body MOSFETs Based on the Potts Model for Solving Complex Combinatorial Optimization Problems. [PDF]

Adv Mater
Cheong S, Lee SH, Han J, Park JY, Shin DH, Jang YH, Shim SK, Kim S, Hwang CS, Han JK.   +9 more
europepmc   +1 more source

Genome-Scale Screening and Combinatorial Optimization of Gene Overexpression Targets to Improve Cadmium Tolerance in Saccharomyces cerevisiae. [PDF]

Front Microbiol, 2021
Chen Y, Liang J, Chen Z, Wang B, Si T.
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Pushing the boundary of quantum advantage in hard combinatorial optimization with probabilistic computers. [PDF]

Nat Commun
Chowdhury S, Aadit NA, Grimaldi A, Raimondo E, Raut A, Lott PA, Mentink JH, Rams MM, Ricci-Tersenghi F, Chiappini M, Theogarajan LS, Srimani T, Finocchio G, Mohseni M, Camsari KY.   +14 more
europepmc   +1 more source