Results 121 to 130 of about 1,967,671 (302)

Rigorous Results in Combinatorial Optimization

Dagstuhl Seminar Proceedings, 2006
Many current deterministic solvers for NP-hard combinatorial optimization problems are based on nonlinear relaxation techniques that use floating point arithmetic. Occasionally, due to solving these relaxations, rounding errors may produce erroneous results, although the deterministic algorithm should compute the exact solution in a finite number ...
openaire   +4 more sources

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Accelerated Driving-Training-Based Optimization for Solving Constrained Bi-Objective Stochastic Optimization Problems

Mathematics
The constrained bi-objective stochastic optimization problem (CBSOP) considers the optimization problem with stochastic bi-objective functions subject to deterministic constraints.
Shih-Cheng Horng, Shieh-Shing Lin
doaj   +1 more source

Proportional Fairness for Combinatorial Optimization

Proportional fairness (PF) is a concept widely studied in the literature, particularly in the fields of telecommunications, network design, resource allocation, and social choice. It aims to distribute utilities in a way that ensures fairness and equity among users while optimizing system performance.
Nguyen, Minh Hieu, Baïou, Mourad, Nguyen, Viet Hung, Vo, Thi Quynh Trang   +3 more
openaire   +2 more sources

Neural combinatorial optimization: A tutorial

Computers & Operations Research
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Angioni D., Archetti C., Speranza M. G.
openaire   +2 more sources

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Advances in LLM-Assisted Combinatorial Optimization

Complex System Modeling and Simulation
Combinatorial optimization (CO) concerns decision-making over discrete solution spaces under constraints and lies at the core of many complex systems across science, engineering, and society.
Chuyue Tian, Ling Wang, Jingfang Chen, Rui Li, Jianmai Shi   +4 more
doaj   +1 more source