Results 101 to 110 of about 63,688 (308)
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Combinatorial ink-jet printing for ceramic discovery [PDF]
, 2006 PhDAn aspirating and dispensing printer established inside a robot gantry equipped with furnace and measurement table is used to prepare thick-film combinatorial libraries.
Wang, Jian
core
Neural combinatorial optimization: A tutorial
Computers & Operations ResearchzbMATH Open Web Interface contents unavailable due to conflicting licenses.
Angioni D., Archetti C., Speranza M. G.
openaire +2 more sources
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
A Scala Embedded DSL for Combinatorial Optimization in Software Requirements Engineering [Elektronisk resurs] [PDF]
, 2013 The goal of the presented work is to provide support for software requirements engineering domain experts in modeling combinatorial optimization problems that arise in requirements prioritization and release planning.
Kuchcinski, Krzysztof, +2 more
core
COMBINATORIAL OPTIMIZATION UNDER UNCERTAINTY AND FORMAL MODELS OF EXPERT ESTIMATION
Вісник Національного технічного університету "ХПÌ": Системний аналіз, управління та інформаційні технології, 2019 Previously, the author formalized the concepts of uncertainty, compromise solution, compromise criteria and conditions for a quite general class of combinatorial optimization problems.
Alexander Anatolievich Pavlov
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
An Agent Based Market Design Methodology for Combinatorial Auctions [PDF]
Auction mechanisms have attracted a great deal of interest and have been used in diverse e-marketplaces. In particular, combinatorial auctions have the potential to play an important role in electronic transactions.
Kun Chang Lee, Gyoo Gun Lim, Jinho Choi
core