Results 101 to 110 of about 1,967,671 (302)
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
, 2017 For many companies it is important to protect their physical and intellectual property in an e cient and economically viable man- ner. Thus, specialized security companies are delegated to guard private and public property.
Kloimüllner, Christian, Raidl, Günther
core +4 more sources
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
Science and Technology of Nuclear Installations, 2015 Assembly sequence planning (ASP) of remote handling maintenance in radioactive environment is a combinatorial optimization problem. This study proposes an improved shuffled frog leaping algorithm (SFLA) for the combinatorial optimization problem of ASP ...
Jianwen Guo +6 more
doaj +1 more source
Binary Cockroach Swarm Optimization for Combinatorial Optimization Problem
Algorithms, 2016 The Cockroach Swarm Optimization (CSO) algorithm is inspired by cockroach social behavior. It is a simple and efficient meta-heuristic algorithm and has been applied to solve global optimization problems successfully.
Ibidun Christiana Obagbuwa +1 more
doaj +1 more source
An Agent Based Market Design Methodology for Combinatorial Auctions [PDF]
Auction mechanisms have attracted a great deal of interest and have been used in diverse e-marketplaces. In particular, combinatorial auctions have the potential to play an important role in electronic transactions.
Kun Chang Lee, Gyoo Gun Lim, Jinho Choi
core
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Combinatorial Optimization with Neural Networks
, 1993 A general introduction to the use of feed-back artificial neural networks (ANN) for obtaining good approximate solutions to combinatorial optimization problems is given, assuming no previous knowledge in the field.
Peterson, Carsten,, Söderberg, Bo,
core
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source