Results 101 to 110 of about 36,738 (263)

Crossover versus Mutation: A Comparative Analysis of the Evolutionary Strategy of Genetic Algorithms Applied to Combinatorial Optimization Problems

The Scientific World Journal, 2014
Since their first formulation, genetic algorithms (GAs) have been one of the most widely used techniques to solve combinatorial optimization problems.
E. Osaba, R. Carballedo, F. Diaz, E. Onieva, I. de la Iglesia, A. Perallos   +5 more
doaj   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Quantum-enhanced greedy combinatorial optimization solver. [PDF]

Sci Adv, 2023
Dupont M, Evert B, Hodson MJ, Sundar B, Jeffrey S, Yamaguchi Y, Feng D, Maciejewski FB, Hadfield S, Alam MS, Wang Z, Grabbe S, Lott PA, Rieffel EG, Venturelli D, Reagor MJ.   +15 more
europepmc   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

A hybrid neural combinatorial optimization framework assisted by automated algorithm design

Complex & Intelligent Systems
In recent years, the application of Neural Combinatorial Optimization (NCO) techniques in Combinatorial Optimization (CO) has emerged as a popular and promising research direction.
Liang Ma, Xingxing Hao, Wei Zhou, Qianbao He, Ruibang Zhang, Li Chen   +5 more
doaj   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Combinatorial Optimization

Combinatorial optimization deals with optimization problems defined on polyhedral constraints or discrete structures such as graphs and networks. In the past thirty years the topic has developed into a rich mathematical discipline with many connections to other fields of mathematics such as combinatorics, group theory, geometry of numbers, convex ...
Dalzell, Alexander M., McArdle, Sam, Salton, Grant, Wang, Samson, Brandão, Fernando G. S. L., Berta, Mario Andrea, Bienias, Przemyslaw, Chen, Chi-Fang, Gilyén, András, Hann, Connor T., Kastoryano, Michael J., Khabiboulline, Emil T., Kubica, Aleksander   +12 more
openaire   +3 more sources

Combinatorial optimization and spatial remodeling of CYPs to control product profile. [PDF]

Metab Eng, 2023
Yang J, Liu Y, Zhong D, Xu L, Gao H, Keasling JD, Luo X, Chou HH.   +7 more
europepmc   +1 more source