Results 171 to 180 of about 4,882,239 (315)

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Analog optical computer for AI inference and combinatorial optimization. [PDF]

Nature
Kalinin KP, Gladrow J, Chu J, Clegg JH, Cletheroe D, Kelly DJ, Rahmani B, Brennan G, Canakci B, Falck F, Hansen M, Kleewein J, Kremer H, O'Shea G, Pickup L, Rajmohan S, Rowstron A, Ruhle V, Braine L, Khedekar S, Berloff NG, Gkantsidis C, Parmigiani F, Ballani H.   +23 more
europepmc   +1 more source

Genome-Scale Screening and Combinatorial Optimization of Gene Overexpression Targets to Improve Cadmium Tolerance in Saccharomyces cerevisiae. [PDF]

Front Microbiol, 2021
Chen Y, Liang J, Chen Z, Wang B, Si T.
europepmc   +1 more source

CEGO: Combinatorial Efficient Global Optimization [PDF]

, 2015
Martin Zaefferer
openalex   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Pushing the boundary of quantum advantage in hard combinatorial optimization with probabilistic computers. [PDF]

Nat Commun
Chowdhury S, Aadit NA, Grimaldi A, Raimondo E, Raut A, Lott PA, Mentink JH, Rams MM, Ricci-Tersenghi F, Chiappini M, Theogarajan LS, Srimani T, Finocchio G, Mohseni M, Camsari KY.   +14 more
europepmc   +1 more source

A Partial Carrier Phase Integer Ambiguity Fixing Algorithm for Combinatorial Optimization between Network RTK Reference Stations. [PDF]

Sensors (Basel), 2021
Wang S, You Z, Sun X.
europepmc   +1 more source

Augmenting Compliance Guaranteed Conversational AI: Context-Aware Knowledge Base Expansion with LLMs and Combinatorial Optimization

Association for Computational Linguistics 2025, He, Yuanqin, Hong, Mengze, Jiang, Di, Zhang, Chen   +4 more
openalex   +1 more source

High-efficiency expression and secretion of human FGF21 in Bacillus subtilis by intercalation of a mini-cistron cassette and combinatorial optimization of cell regulatory components [PDF]

, 2019
Dandan Li, Gang Fu, Ran Tu, Zhaoxia Jin, Dawei Zhang   +4 more
openalex   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source