Results 71 to 80 of about 4,919,639 (299)
Geometrical Theory on Combinatorial Manifolds [PDF]
, 2005 Topological and differential structures such as those of d-pathwise connected, homotopy classes, fundamental d-groups in topology and tangent vector fields, tensor fields, connections, Minkowski norms in differential geometry on these finitely ...
Mao, Linfan
core +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Mathematical modeling of finite topologies
Karpatsʹkì Matematičnì Publìkacìï, 2020 Integer programming is a tool for solving some combinatorial optimization problems. In this paper, we deal with combinatorial optimization problems on finite topologies.
S.E. Monabbati, H. Torabi
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Differential evolution for permutation-based combinatorial problems
, 2012 The chapter clarifies the differences between wide-sense combinatorial optimization and strict-sense combinatorial optimization and then presents a number of combinatorial problems encountered in practice.
Davendra, Donald David +3 more
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Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Algorithm for Solving and Updating Combinatorial Skyline [PDF]
Jisuanji gongcheng, 2017 Existing algorithms for querying combinatorial Skyline have low pruning efficiency and unsatisfactory computing speed for low-dimensional data set.Aiming at these problems,this paper proposes a fast algorithm for solving and updating combinatorial ...
DONG Leigang,LIU Guohua
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ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Recursive Quantum Relaxation for Combinatorial Optimization Problems [PDF]
QuantumQuantum optimization methods use a continuous degree-of-freedom of quantum states to heuristically solve combinatorial problems, such as the MAX-CUT problem, which can be attributed to various NP-hard combinatorial problems.
Ruho Kondo +3 more
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