Results 71 to 80 of about 46,411 (355)

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Changes in yield and composition of barley, wheat and triticale grains harvested during advancing stages of ripening [PDF]

, 2006
peer-reviewedThis study involved an evaluation of the changes in grain yield, nutritive value, ensilability and harvesting losses of intensively managed winter cereals harvested during the advancing stages of ripening.
Hackett, Richard, O'Kiely, Padraig, O'Mara, Frank P., Rice, B., Stacey, Pamela   +4 more
core  

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Evaluation of the operation of the fan of the combine harvester air-and-screen cleaning system when using an asynchronous electric motor as a drive [PDF]

BIO Web of Conferences
The article presents the results of a study of a combine harvester fan after making design changes aimed at facilitating air flow control in airand-screen cleaning.
Pustovaya O.A., Pustovoy E.A., Usanov V.S., Sakharov V.A., Lipkan A.V., Kuvshinov A.A.   +5 more
doaj   +1 more source

Структурный анализ надежности зерноуборочного комбайна [PDF]

, 2006
Рассмотрено зерноуборочный комбайн как сложную многооперационную систему. Составлены графы состояния комбайна в период его эксплуатации и определены значения вероятности нахождения в каждом из состояний.
Мороз, Н. Н.
core  

Investigating the influence of fine-dispersed aluminum, nickel and titanium on the properties of phenylone [PDF]

, 2019
Розглянуто вплив металевих наповнювачів на фізико-механічні та трибологічні характеристики ароматичного поліаміду фенілон – багатообіцяючий термостійкий полімер конструкційного призначення, який може довго експлуатуватися до температури 533 К та не ...
Burya, Aleksandr, Rybak, Timofiy, Yeriomina, Yekaterina, Буря, Олександр, Рибак, Тимофій Іванович, Єрьоміна, Катерина Андріївна   +5 more
core   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Lábon álló kalászosok közvetlen cséplésének kutatása = Direct threshing of unmown cereal [PDF]

, 2008
A 2004-2007 közötti pályázati időszakban két területen folytattunk kutatásokat: az eredeti cél szerinti - lábon álló kalászosok közvetlen cséplésével, valamint - nagy munkaszélességű, vékony rétegű csépléssel Közvetlen kalászcséplésnél az ...
Kurtán, Sándor, Láng, Zoltán, Nagy, Sándor   +2 more
core  

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source